114748-71-9 Usage
General Description
7-TFA-ap-7-Deaza-ddA is a synthetic analog of the nucleoside adenosine, with a trifluoroacetyl (TFA) group at the 7-position and a 7-deaza modification. It is a potential antiviral agent, as it can act as a chain terminator during DNA replication in viruses, thus inhibiting their ability to replicate. 7-TFA-ap-7-Deaza-ddA has been studied for its potential use in the treatment of viral infections, particularly those caused by DNA viruses such as herpesviruses. Additionally, 7-TFA-ap-7-Deaza-ddA has been investigated for its potential use in research on nucleoside analogs and their mechanisms of action in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 114748-71-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,7,4 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 114748-71:
(8*1)+(7*1)+(6*4)+(5*7)+(4*4)+(3*8)+(2*7)+(1*1)=129
129 % 10 = 9
So 114748-71-9 is a valid CAS Registry Number.
114748-71-9Relevant articles and documents
The Use of Heterocyclic Chemistry in the Synthesis of Natural and Unnatural Products
Confalone, Pat. N.
, p. 31 - 46 (2007/10/02)
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Palladium-Catalyzed Synthesis of Alkynylamino Nucleosides. A Universal Linker for Nucleic Acid
Hobbs, Frank W.
, p. 3420 - 3422 (2007/10/02)
A method for attaching alkynylamino "linkers" to nucleosides and nucleotides is described.Protected or unprotected alkynylamines are coupled to iodonucleosides in dimethylformamide using a 1:2 mol ratio of tetrakis(triphenylphosphine)palladium(0) and copper(I) iodide, a catalyst system superior to the standard system using palladium(II) species.The resulting alkynylamino nucleosides are useful for enzymatic or chemical labeling of all four bases of DNA.
