40725-89-1

Basic information

• Product Name: 3'-Deoxytubercidin
• Synonyms: 3'-Deoxytubercidin;7-(3-Deoxy-beta-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;NSC 124154
• CAS NO: 40725-89-1
• Molecular Formula: C₁₁H₁₄N₄O₃
• Molecular Weight: 250.2539
• Mol File: 40725-89-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 601.3°Cat760mmHg
• Flash Point: 317.5°C
• Appearance: /
• Density: 1.75g/cm³
• Vapor Pressure: 2.62E-15mmHg at 25°C
• Refractive Index: 1.797
• CAS DataBase Reference: 3'-Deoxytubercidin(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Deoxytubercidin(40725-89-1)
• EPA Substance Registry System: 3'-Deoxytubercidin(40725-89-1)

Safety Data

• Hazardous Substances Data: 40725-89-1(Hazardous Substances Data)

Usage

General Description

3'-Deoxytubercidin is a synthetic chemical compound that belongs to the class of nucleoside analogues. It is a modified form of adenosine, with the hydroxyl group at the 3' position of the sugar ring replaced by a hydrogen atom. This modification makes the compound resistant to degradation by adenosine deaminase, an enzyme that breaks down adenosine in the body. 3'-Deoxytubercidin has been studied for its potential anti-cancer and anti-viral activities, as well as its ability to inhibit RNA synthesis. It has also been investigated as a potential drug for the treatment of autoimmune diseases and inflammatory conditions. However, more research is needed to fully understand the therapeutic potential and mechanisms of action of this compound.

InChI:InChI=1/C11H14N4O3/c12-9-7-1-2-15(10(7)14-5-13-9)11-8(17)3-6(4-16)18-11/h1-2,5-6,8,11,16-17H,3-4H2,(H2,12,13,14)/t6-,8+,11+/m0/s1

Upstream product

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• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
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Downstream Products

• 40627-30-3 2',3'-dideoxytubercidin 
• 128878-82-0 4-amino-7-<3-deoxy-5-O-4-methoxytrityl-2-O-phenoxy(thiocarbonyl)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 135885-06-2 7-{(2R,5S)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 

Relevant articles and documents

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Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.