- Phase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles
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A general phase-transfer-catalyzed asymmetric (n+1) (n = 4 or 5) annulation reaction, featuring the direct coupling of simple oxindoles with alkyl dihalides that are allylic/benzylic and non-allylic/benzylic, has been developed to provide previously inacc
- Gao, Min,Hu, Lin,Li, Xuemin,Li, Yongyi
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supporting information
p. 875 - 880
(2022/02/05)
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- Bromine-induced facile synthesis of butenolides and spirobutenolides from sterically congested tetrasubstituted dialkyl alkylidene succinates
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Starting from sterically congested tetrasubstituted dialkyl alkylidene succinates, facile general approach to several dialkyl substituted butenolides and spirobutenolides with the generation of quaternary carbon center has been demonstrated via bromine-in
- Patel, Ramesh M.,Argade, Narshinha P.
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experimental part
p. 1188 - 1194
(2010/05/19)
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- Synthesis of (E)-3-alkylidenepyrrolidines by nucleophilic ring closure of (E)-2-alkylidene-1,4-diol derivatives
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The synthesis of N-protected (E)-3-alkylidenepyrrolidines is reported. Nitroalkanes react with unsaturated 1,4-diesters and 1,4-keto esters, giving a tandem Michael addition/elimination of nitrous acid. The obtained 1,4-dicarbonyl compounds are reduced to the corresponding diols and then converted into their mesylates. Reaction of mesylates with benzylamine or 4-methylbenzenesulfonylamide affords the unsaturated pyrrolidines. Use of the sulfonylamide for the cyclization step has advantages over that of benzylamine, since it gives better yields of pyrrolidines, and furthermore, the benzenesulfonyl group can be efficiently removed in the presence of unsaturated bonds.
- Ballini, Roberto,Bosica, Giovanna,Mase?, Aldo,Petrini, Marino
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p. 2927 - 2931
(2007/10/03)
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- Nitroalkanes as a new source of 2-alkylidene-1,4-diols, in two steps
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A variety of 2-alkylidene-1,4-diols have been conveniently prepared, in two steps, by conjugate addition of a nitroalkane to the appropriate enedione derivatives under basic conditions (DBU), followed by chemoselective reduction (LiAlH4/Et2O) of the carbonyl functionalities of the Michael adduct, obtained after elimination of nitrous acid.
- Ballini, Roberto,Bosica, Giovanna,Damiani, Marco,Righi, Paolo
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p. 13451 - 13456
(2007/10/03)
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- Stereochemistry of Cyclohexylidene(arylidene)succinates Formed in the Stobbe Condensation
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The diacids obtained from acid-esters 1-cyclohexylidene-2-carbomethoxy-3-arylprop-2-ene-1-carboxylic acids (5a) and 1-cyclohexylidene-1-carbomethoxy-3-arylprop-2-ene-2-carboxylic acids (5b) are identical.This along with the physico-chemical studies clearl
- Banerjee , S.,Bagavant, G.
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p. 362 - 365
(2007/10/02)
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