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40762-15-0

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A new series of benzodiazepines. 1 hydroxyalkyl derivatives of 1,3 dihydro 2H 1,4 benzodiazepin 2 ones
A series of new 1 hydroxyalkyl derivatives of 1,3 dihydro 2H 1,4 benzodiazepin 2 ones bearing a 3 hydroxyl or a 4 N oxide function together with some related compounds have been synthesized. Compound [1 (2 hydroxyethyl) 3 hydroxy 7 chloro 1,3 dihydro 5 (o fluorophenyl) 2H 1,4 benzodiazepin 2 one] has been selected for further studies both in animals and in humans as an antianxiety sedative agent.
Tamagnone,De Maria,De Marchi
p. 720 - 722
(2007/10/09)

A new benzodiazepine: 1 (2 hydroxyethyl) 3 hydroxy 7 chloro 1,3 dihydro 5 (o fluorophenyl) 2H 1,4 benzodiazepin 2 one
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Tamagnone,Torrielli,De Marchi
p. 566 - 567
(2007/10/09)

Chemical Properties

Boiling Point: 618.4°Cat760mmHg
Flash Point:327.8°C
Density: 1.45g/cm³
Vapor Pressure: 3.77E-16mmHg at 25°C
PSA: 73.13000
LogP: 1.47440

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