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Basic Information
CAS No.: 40762-15-0
Name: Doxefazepam
Article Data: 3
Molecular Structure:
Molecular Structure of 40762-15-0 (Doxefazepam)
Formula: C17H14 Cl F N2 O3
Molecular Weight: 348.761
Synonyms: 1-(2-Hydroxyethyl)-3-hydroxy-7-chloro-1,3-dihydro-5-(o-fluorophenyl)-2H-1,4-benzodiazepin-2-one;Doxans; Doxefazepam; N-1-Hydroxyethyl-3-hydroxyflurazepam; SAS 643
Density: 1.45g/cm3
Boiling Point: 618.4°Cat760mmHg
Flash Point: 327.8°C
Safety: Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by an unspecified route: somnolence. When heated to decomposition it emits very toxic fumes of Cl, F, and NOx.
PSA: 73.13000
LogP: 1.47440
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Toxicity Data With Reference

1.   

unr-hmn TDLo:71 µg/kg:CNS

    DRFUD4    Drugs of the Future. 3 (1978),145.
2.   

orl-rat LD50:2550 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 25 (1975),1294.
3.   

ipr-rat LD50:586 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 25 (1975),1294.
4.   

ipr-mus LD50:760 mg/kg

    JPPMAB    Journal of Pharmacy and Pharmacology. 26 (1974),566.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by an unspecified route: somnolence. When heated to decomposition it emits very toxic fumes of Cl, F, and NOx.