Evaluation of the Cytotoxic Activity of Chiral (E)-13-Hydroxy-10-oxo-11-octadecenoic Acid and Its Lactone
Both the S and R enantiomers of (E)-13-hydroxy-10-oxo-11-octadecenoic acid (1) and (E)-10-oxo-11-octadecen-13-olide (2) had similar IC50 values against P388 mouse leukemia cells; i.e. the stereochemistry of the asymmetric center of 1 and 2 had no influence on the cytotoxic activity. Bioassay results of various compounds related to 1 and 2 suggests that the 1O-oxo and lactone moieties of 2 were important for enhancing the cytotoxicity. - Keywords: corn; cytotoxicity; fatty acid; (E)-13-hydroxy-10-oxo-11octadecenoic acid; (E)-10-oxo-11-octadecen-13-olide.