Light-induced [2 + 2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides
Cyclobutanes are an important class of motifs present in a wide range of natural products and other biologically significant molecules. A photocatalytic [2 + 2] cycloaddition between pyridones or isoquinolones and ethenesulfonyl fluoride was achieved, providing a portal to a class of unique cyclobutane-fused pyridinyl sulfonyl fluorides with quaternary rigid rings (30 examples). Further applications of these novel sulfonyl fluoride molecules in SuFEx click chemistry were also accomplished, providing the corresponding sulfonates and sulphonamides with reasonable yields.
Liu, Jing,Wang, Shi-Meng,Qin, Hua-Li
supporting information
p. 4019 - 4023
(2020/06/09)
ACLY INHIBITORS AND USES THEREOF
The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.
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Paragraph 00642
(2020/06/01)
Iron-catalyzed regioselective direct arylation at the C-3 position of N-alkyl-2-pyridone
A number of pharmaceutical compounds possess an arylated 2-pyridone moiety. The existing reports using expensive starting materials and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method for their synthesis. In this report, we demonstrate an easy-to-handle reaction condition with an iron catalyst for the exclusive generation of C-3-arylated pyridone via C-H functionalization.
Modak, Atanu,Rana, Sujoy,Maiti, Debabrata
p. 296 - 303
(2016/09/09)
Polyhalogenoaromatic Compounds. Part 42. 13C N.m.r. Spectra of Polyhalogeno-pyridines and pyrimidines
13C N.m.r. spectra are reported for a number of polyhaloheno-pyridines and -pyrimidines.Substituent effects have been calculated and the results used to assign structures.
Iddon, Brian,Mack, Arthur G.,Suschitzky, Hans,Taylor, Jack A.,Wakefield, Basil J.
p. 1370 - 1380
(2007/10/02)
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