First practical synthesis of enantiomerically pure (R)- and (S)-desmethylsibutramine (DMS) and unambiguous determination of their absolute configuration by single-crystal X-ray analysis
A practical synthesis of enantiomerically pure (R)-desmethylsibutramine [(R)-DMS] and (S)-desmethylsibutramine [(S)-DMS] is outlined along with an improved synthesis of racemic desmethylsibutramine. This route was used for kilo-scale production of enantio
Han, Zhengxu,Krishnamurthy, Dhileepkumar,Pflum, Derek,Fang, Qun K.,Butler, Hal,Cameron,Wald, Stephen A.,Senanayake, Chris H.
New resolution approach for large-scale preparation of enantiopure didesmethylsibutramine (DDMS)
An improved synthesis and efficient resolution method to prepare both enantiopures of DDMS using crystallization of enantiomerically pure tartaric acid salts of racemic DDMS are disclosed.
Han, Zhengxu,Krishnamurthy, Dhileepkumar,Fang, Q. Kevin,Wald, Stephen A.,Senanayake, Chris H.
p. 3553 - 3556
(2007/10/03)
More Articles about upstream products of 421558-88-5