- Synthesis of n-methyl benzenemethane sulfonamide substituted carbazoles and pyrazoles
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Cyclization of 1-(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride (2) with cyclohexanone (3)/N-methyl-4-piperidone (5) afforded the corresponding N-methyl-1-(2,3,4,9-tetrahydro-1H-carbazol-6-yl)methanesulfonamide (4) and N-methyl-1-(2-methyl- 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl) methane sulfonamide (6). Condensation of compound 2 with substituted aryl β-diketones gave the novel N-methyl-1-[4-(3-methyl-5-phenyl-1H-pyrazol-1- yl)phenyl]methanesulfonamide (8). All the synthesized compounds were characterized by their FT-IR, 1H NMR and mass spectral data.
- Rao, B. Venugopala,Hariharakrishnan,Dubey
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scheme or table
p. 1191 - 1194
(2012/08/07)
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- 5-substituted-3-aminoalkyl indole derivatives for migraine
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Indole derivatives are disclosed of the general formula (I): STR1 wherein R1 is hydrogen, C1-6 alkyl or C3-6 alkenyl; R2 is a hydrogen, C1-3 alkyl, C3-6 alkenyl, phenyl, phen(C1-4)alkyl or C5-7 cycloalkyl; R3 and R4 are hydrogen, C1-3 alkyl or propenyl groups or together form an aralkylidene group; Alk is C2 -C3 alkylene chain and A is C2 -C5 alkylene chain and its physiologically acceptable salts and solvates. The compounds may be prepared, for example, by cyclization of a compound of general formula (II): STR2 where Q is the group NR3 R4 or a protected derivative thereof or a leaving group and R1 l, R2, R3, R4, A and Alk are as defined for formula (I). The compounds have a selective vosoconstrictor action and are useful in treating pain such as migraine. The compounds may be formulated as pharmaceutical compositions in conventional manner, preferably for oral administration.
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