42381-27-1

Basic information

• Product Name: 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride
• Synonyms: p-[beta-(Methylsulfonamido)ethyl]phenylhydrazine hydrochloride;4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride;4-HYDRAZINO-N-METHYLBENZENETHANESULFONAMIDE HYDROCHLORIDE;4-HYDRAZINO-N-METHTYL BENZENE ETHANE SULFONAMIDE HCL;4-HYDROZINO-N-METHYLBENZENE ETHANE SULFONAMIDE HCL;4-HYDRAZINOPHENYL-N-METHYLETHANE SULFANOAMIDE;4-Hydrazinyl-N-MethylbenzeneethanesulfonaMide Hydrochloride;p-[β-(MethylsulfonaMido)ethyl]phenylhydrazine Hydrochloride
• CAS NO: 42381-27-1
• Molecular Formula: C₉H₁₅N₃O₂S*ClH
• Molecular Weight: 265.76
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 42381-27-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 459.2 °C at 760 mmHg
• Flash Point: 231.5 °C
• Appearance: yellow to light yellow crystal powder
• Vapor Pressure: 7.79E-09mmHg at 25°C
• CAS DataBase Reference: 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride(42381-27-1)
• EPA Substance Registry System: 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride(42381-27-1)

Safety Data

• Hazardous Substances Data: 42381-27-1(Hazardous Substances Data)

Usage

Description

4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals. It is a yellow to light yellow crystalline powder, which is a characteristic of its chemical properties.

Uses

Used in Pharmaceutical Industry:
4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride is used as an intermediate in the preparation of the antimigraine drug Naratriptan (N378730). It plays a crucial role in the synthesis process, contributing to the development of medications that help alleviate migraine symptoms and improve the quality of life for patients suffering from this condition.
As a Naratriptan intermediate, 4-Hydrazino-N-methylbenzeneethanesulfonamide hydrochloride is essential in the pharmaceutical industry for the production of effective treatments for migraines. Its chemical properties and structure make it a valuable component in the synthesis of Naratriptan, which is a selective serotonin agonist that works by narrowing blood vessels in the brain and reducing the release of substances that cause inflammation, pain, and other migraine symptoms.

InChI:InChI=1/C9H15N3O2S.ClH/c1-11-15(13,14)7-6-8-2-4-9(12-10)5-3-8;/h2-5,11-12H,6-7,10H2,1H3;1H

Upstream product

• 98623-16-6 2-(4-amino-phenyl)ethanesulfonic acid methylamide 

Downstream Products

• 1364283-47-5 C₁₇H₁₉N₃O₂S₂ 
• 1364283-53-3 C₁₉H₁₈F₃N₃O₂S 
• 1363256-89-6 C₂₀H₂₀F₃N₃O₂S 
• 1204192-94-8 2-(3-phenylsulfanyl-1H-indol-5-yl)ethanesulfonicacid methylamide 
• 1025797-49-2 2-{[4-(2-methylsulfamoyl-ethyl)-phenyl]-hydrazono}-propionic acid ethyl ester 

Relevant articles and documents

Synthesis of n-methyl benzenemethane sulfonamide substituted carbazoles and pyrazoles

Cyclization of 1-(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride (2) with cyclohexanone (3)/N-methyl-4-piperidone (5) afforded the corresponding N-methyl-1-(2,3,4,9-tetrahydro-1H-carbazol-6-yl)methanesulfonamide (4) and N-methyl-1-(2-methyl- 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl) methane sulfonamide (6). Condensation of compound 2 with substituted aryl β-diketones gave the novel N-methyl-1-[4-(3-methyl-5-phenyl-1H-pyrazol-1- yl)phenyl]methanesulfonamide (8). All the synthesized compounds were characterized by their FT-IR, 1H NMR and mass spectral data.