- Continuous synthesis method of hydroxypyrimidine compound
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The invention discloses a continuous synthesis method of a hydroxypyrimidine compound. The method comprises the steps: carrying out continuous reaction on organic amine and a 50% cyanamide aqueous solution in a micro-reactor, introducing the reaction solution into a liquid separator for continuous phase splitting, carrying out continuous ring closing on a guanidine solution and alpha-alkyl acetoacetate in a second micro-reactor, washing the reaction solution with water, and desolventizing to obtain a target product. The method is based on the concept of green chemistry, the comprehensive costof raw materials is far lower than that of traditional methods, no salt-containing wastewater is generated, and treatment is easy; traditional solid-liquid separation is avoided, automatic productionis facilitated, and the safety and environmental protection level of the device is improved; continuous synthesis is adopted, decomposition of an intermediate is avoided, the total yield is larger than 82%, and the product content reaches 98%.
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Paragraph 0012; 0028-0029
(2020/07/28)
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- Synthetic method of hydroxypyrimidine compound
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The invention discloses a synthesis method of a hydroxypyrimidine compound, which comprises the following steps: adding alkyl guanidine salt into a methanol or ethanol solvent, adding a neutralizing reagent to carry out a neutralization reaction, filtering, and removing the solvent from the filtrate to obtain the residue alkyl guanidine; mixing alkyl guanidine with alkyl alpha-alkylacetoacetate, reacting in an inert atmosphere at 90-140 DEG C until water and methanol are separated, cooling to 60-80 DEG C after the reaction is finished, adding alkyl hydrocarbon into the reaction solution, stirring for 10-30 minutes, cooling to room temperature, filtering and washing to obtain the hydroxypyrimidine compound. According to the synthesis method, no solvent reaction exists, so that the single-kettle reaction efficiency is greatly improved; in addition, dehydration and degreasing are carried out in an inert atmosphere, so that deterioration of alkyl alpha-alkylacetoacetate at high temperatureis effectively avoided, and the reaction safety is also improved. Therefore, the synthesis method disclosed by the invention has the advantages of high single-kettle reaction efficiency, high safetyand less three wastes.
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Paragraph 0075-0077
(2020/12/08)
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- Acid dye for polyamide fiber dyeing and preparation method thereof (by machine translation)
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The invention discloses an acid dye, for polyamide fiber dyeing, which has a chemical structural general formula of: R Is an aromatic sulfonic acid group . and the invention also provides a preparation method. of the acid dye, and the acid dye, prepared by the invention does not contain a heavy metal, as a novel acid dye and has excellent water treatment fastness, and bright color light. (by machine translation)
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Paragraph 0040; 0043-0044
(2020/03/25)
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- Acetyl hydrazone derivative containing pyrimidine structure and preparation method and application thereof
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The invention discloses an acetyl hydrazone derivative containing a pyrimidine structure and a preparation method and application thereof. The preparation method comprises the following steps of reacting ethyl acetoacetate and 1,1-diethylguanidine hydrochloride to generate a compound (II); stirring the compound (II) and 2-ethyl chloroacetate at room temperature to synthesize a compound (III); performing refluxing reaction on the compound (III) and 85% hydrazine hydrate to obtain a synthetic compound (IV); synthesizing the compound (IV) and substituted aldehyde by a microwave method, so as to synthesize a target compound (I). By adopting the technique, the acetyl hydrazone derivative containing the pyrimidine structure has the advantages that the raw materials are simple and easy to obtain, the preparation method is simple, the post-treatment is convenient, and the yield rate of products is high; the synthetic compound (I) is radiated by the microwaves, and the yield rate is 10% or above; the aedes aegypti killing activity is realized, and good mosquito killing effect is realized.
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Paragraph 0013; 0023
(2017/07/20)
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- Acetic acid derivatives and processes for their production
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A process for the preparation of a compound of formula: STR1 wherein R is an amino, hydrocarbylamino or dihydrocarbylamino radical, the hydrocarbylamino and dihydrocarbylamino radicals being unsubstituted, or substituted in the hydrocarbyl moiety with atoms or radicals which do not interfere with the process and Z is an acyl radical which comprises the steps of: (a) decarboxylating a compound of formula: STR2 to produce the corresponding 4-hydroxy-6-methyl-pyrimidine; and (B) TREATING THE CORRESPONDING 4-HYDROXY-6-METHYL PYRIMIDINE THUS PRODUCED WITH AN ACYLATING AGENT CAPABLE OF PROVIDING THE ACYL RADICAL Z; where both steps (a) and (b) are carried out in the same solvent or diluent.
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- Process of preparing 2-amino-4-hydroxy-5(and/or 6)-alkyl substituted pyrimidines
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Process for the preparation of a compound of formula: STR1 WHEREIN N IS ZERO OR AN INTEGER FROM 1 TO 12 AND R1 and R2 are hydrogen or lower alkyl, which comprises the step of treating a mixture of a diketene of formula: STR2 and a strongly acidic medium selected from the group consisting of concentrated sulphuric acid and oleum with a compound of formula: NH=C(NH2)NR1 R2 or the sulphate thereof.
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