- Carboxylic acid derivative compound and its preparation method and application
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The invention provides a carboxylic acid derivative compound. The compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof provided by the invention not only can reduce the level of triglyceride in high fat model animal blood, but also has the good function of reducing cholesterol and low-density lipoprotein and the effects of promoting biliation, reducing content of cholesterol in bile and increasing the content of bile acid, and also has the effect of preventing and treating gallstone when being applied to a golden gopher gallstone model. The particular importance is that the compound or the pharmaceutically acceptable salt thereof provided by the invention is low in toxicity.
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Paragraph 0089; 0090
(2017/01/31)
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- Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging
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Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW ~ 205.19, λab ~ 350 nm, λem ~ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues. This journal is
- Miao, Jianzhuang,Cui, Huaqing,Jin, Jing,Lai, Fangfang,Wen, Hui,Zhang, Xiang,Ruda, Gian Filippo,Chen, Xiaoguang,Yin, Dali
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p. 881 - 884
(2015/02/19)
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- Synthesis of [4-14C]-pelargonidin chloride and [4- 14C]-delphinidin chloride
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The synthesis of [4-14C]-pelargonidin chloride and [4- 14C]-delphinidin chloride via [formyl-14C]-2-(benzoyloxy)- 4,6-dihydroxybenzaldehyde, ω,4-diacetoxyacetophenone and ω,3,4,5-tetraacetoxyacetophenone is described. The first step comprised labelling of the carbonyl group of 2-(benzoyloxy)-4,6-dihydroxybenzaldehyde, verifying that the coupling with ω,4-diacetoxyacetophenone or ω,3,4,5-tetraacetoxyacetophenone under hydrogen chloride atmosphere resulted in the formation of [4-14C] labelled anthocyanidins. Copyright
- Kraus, Michael,Biskup, Ellen,Richling, Elke,Schreier, Peter
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p. 1151 - 1162
(2007/10/03)
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- Facile synthesis of glycol metabolites of phenethylamine drugs
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High yields of potential glycol metabolites of p-synephrine, epinephrine, octopamine, and normacromerine can be obtained from the readily available monosubstituted and disubstituted acetophenones. The general procedure involves alpha-bromination followed by displacement with acetate ion and reduction with lithium aluminum hydride. Yields ranged from 46 to 91%. Furthermore, the procedure minimizes some problems inherent in aromatic glycol synthesis which include dimerization and pinacol-pinacolone rearrangement.
- Holshouser,Kolb
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p. 619 - 621
(2007/10/02)
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