cas 42540-40-9, Cemandil sodium salt | Articles data

Articles about 42540-40-9Total 7 be found

Synthetic method of L-type cefamandole nafate
The invention provides a synthesis method of L-type cefamandole nafate, which comprises the following steps of carrying out silanization reaction on 7-ATCA and a silane protective agent in the presence of an organic solvent, carrying out acylation reaction with L-formyl mandelic acid chloride, removing silane protective groups, carrying out salification reaction with a sodium salt solution, and carrying out freeze drying to obtain an L-type cefamandole nafate solid. The invention provides an efficient and simple synthetic method of L-type cefamandole nafate.
-
Paragraph 0057-0064

(2021/04/26)

1/4 head spore Meng Duozhi sodium compound (by machine translation)
The invention discloses 1/4 head spore Meng Duozhi sodium compound and its preparation method, each of the plurality of containing sodium molar spore Meng 1/4 mole water. The method of the invention for preparing the compounds of the spore Meng Duozhi sodium, low impurity content, good stability, and good fluidity, the moisture and small, with more extensive application prospects. (by machine translation)
-
Paragraph 0025; 0027; 0028; 0029; 0031; 0032-0033; 0035-0036

(2017/07/20)

Synthesis method for dextrorotation cefamandole nafate
The invention discloses a synthesis method for dextrorotation cefamandole nafate. The method includes the steps that in one-element organic solvent, 7-ACA and 1-methyl-1h-tetrazole-5-thiol are subjected to condensation with a boron trifluoride complex of the one-element organic solvent as a catalyst so as to generate 7-ATCA; and then, in another one-element organic solvent, under the effect of organic alkali, the 7-ATCA and S-(-)-formylmandeloyl chloride are made to react so as to generate the dextrorotation cefamandole nafate, then, an organic phase is left after hydrolysis and extraction phase splitting, organic acid sodium salt and another organic solvent indissolvable in dextrorotation cefamandole sodium are added, the dextrorotation cefamandole sodium is obtained through crystallization, finally, the dextrorotation cefamandole sodium is dissolved in water, organic solvent incapable of being dissolved in water is added together with organic or inorganic acid, an organic phase is left after extraction phase splitting, and reduced pressure rotary evaporation is conducted on the organic phase to obtain the dextrorotation cefamandole nafate. The method is simple, conditions are gentle, raw materials are easy to obtain, and purity of the finally-obtained product is 99% or above.
-
(2017/08/28)

Method for improving quality of cemandil sodium by using three-dimensional column plate to purify solvent
The present invention discloses a method for improving the quality of cemandil sodium by using a three-dimensional column plate to purify a solvent. The method comprises: solvent purification, alkylation reaction, cefamandole ester synthesis, extraction, cemandil sodium synthesis, and sterile sub-packaging. According to the present invention, during the cemandil sodium preparation process, the reaction system solvent is purified by using the high-throughput efficient three-dimensional mass transfer column tray technology so as to finally improve the quality of the cemandil sodium product and ensure the quality of the cemandil sodium powder-needle preparation for injection. The invention provides the method for improving the quality of the cemandil sodium powder-needle preparation for injection by using the three-dimensional column tray mass transfer technology to purify the organic solvent.
-
Paragraph 0046; 0053; 0060; 0067

(2017/05/10)

Cefamandole nafate for reducing anaphylaxis and preparation thereof
The invention relates to an antibiotic drug, in particular to cefamandole nafate for reducing anaphylaxis. The compound has the advantages of high yield, high purity and the like, and is suitable for industrial production, and product stability and anaphylaxis reducing and clinic application of a preparation are all obviously improved .
-
(2016/12/01)

PROCESS FOR THE PREPARATION OF CEFAMANDOLE NAFATE
The present invention relates to a process for the preparation of cefamandole nafate from cefamandole and to the use thereof in the manufacture of a medicament for treatment of a bacterial disease.
-
Page/Page column 10-11

(2013/05/09)

PROCESS FOR THE FORMYLATION OF CEFAMANDOLE
The present invention relates to a process for the preparation of O-formyl cefamandole, an intermediate in the preparation of cefamandole nafate, by formylation of cefamandole.
-
Page/Page column 11

(2013/05/09)