- Synthetic method of L-type cefamandole nafate
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The invention provides a synthesis method of L-type cefamandole nafate, which comprises the following steps of carrying out silanization reaction on 7-ATCA and a silane protective agent in the presence of an organic solvent, carrying out acylation reaction with L-formyl mandelic acid chloride, removing silane protective groups, carrying out salification reaction with a sodium salt solution, and carrying out freeze drying to obtain an L-type cefamandole nafate solid. The invention provides an efficient and simple synthetic method of L-type cefamandole nafate.
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Paragraph 0055; 0056
(2021/04/26)
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- Spirocyclic Side-chain Derivatives of Penicillin and Cephalosporin
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A series of two spirocyclic oxazolidinone derivatives of penicillin and four derivatives of cephalosporin have been prepared, as well as a benzoxazine conjugate of cephalosporin, with the object of freezing the conformation of the 6(7)-amide side-chain bearing a pendant aromatic ring.The antibacterial properties of these derivatives are discussed.
- Sammes, Peter G.,Smith, Steven,Ross, Barry C.
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p. 2117 - 2124
(2007/10/02)
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