- Application of Cp2TiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to [ a]-Annelated Indoles
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An efficient and novel route for assembling pyrrolo/piperido[1,2-a]indoles is portrayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step. Capitalizing on the operational simplicity of the method involving just two steps and use of an efficient C-C bond-forming reaction, this radical-based protocol enables the modular assembly of an important class of N-fused indole derivatives with versatile functional and structural diversity.
- Khan, Hina P. A.,Chakraborty, Tushar Kanti
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- A 4 - mercapto -1 - butanol synthesis process
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The present invention discloses a 4-mercapto-1-butanol synthesis process, which comprises: 1) dissolving 1,4-butanediol and an acid-binding agent in an organic solvent I, adding a sulfonylation agent in a dropwise manner to carry out a sulfonylation reaction, carrying out extraction separation with dichloromethane, and carrying out washing, drying and concentration to obtain a colorless oil-like substance; and 2) dissolving the colorless oil-like substance obtained in the step 1) in an organic solvent II, adding a nucleophile to carry out a nucleophilic substitution reaction, and finally carrying out pressure reducing distillation to obtain the 4-mercapto-1-butanol. According to the present invention, the completely-new 4-mercapto-1-butanol synthesis route is provided, the used raw materials are easy to obtain, the operation is simple, the reaction conditions are not harsh, and good industrial values are provided.
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Paragraph 0027; 0028; 0029
(2017/05/02)
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- Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: Asymmetric synthesis and biological activities
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(Chemical Equation Presented) A convergent and high-yielding approach for the asymmetric synthesis of sulforaphane 2 and four analogues differently substituted at the sulfinyl sulfur has been developed. The key step of the synthesis is the diastereoselect
- Khiar, Noureddine,Werner, Sabine,Mallouk, Siham,Lieder, Franziska,Alcudia, Ana,Fernandez, Inmaculada
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experimental part
p. 6002 - 6009
(2009/12/26)
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