42729-95-3 Usage
Description
1,4-Butanediol, monomethanesulfonate, also known as 4-Methanesulfonyloxybutanol, is a chemical compound derived from the hydrolysis of busulfan, an alkylating agent with antileukemic activity. It is characterized by its ability to form a monomethanesulfonate ester with 1,4-butanediol, which contributes to its unique properties and potential applications.
Uses
Used in Pharmaceutical Industry:
1,4-Butanediol, monomethanesulfonate is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly for the production of busulfan, an alkylating agent with antileukemic activity. Its role in the synthesis process is crucial for the development of drugs that target and treat leukemia.
Used in Cancer Treatment:
1,4-Butanediol, monomethanesulfonate is used as a precursor for the production of busulfan, which is an effective antileukemic agent. Busulfan is employed in the treatment of various types of leukemia, including chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML). 1,4-Butanediol, monomethanesulfonate's alkylating properties enable it to interfere with the DNA replication process in cancer cells, ultimately leading to cell death and tumor regression.
Used in Research and Development:
1,4-Butanediol, monomethanesulfonate is also utilized in research and development for the study of its chemical properties and potential applications in various fields. Its unique structure and reactivity make it an interesting compound for further investigation and potential development of new drugs and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 42729-95-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,7,2 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42729-95:
(7*4)+(6*2)+(5*7)+(4*2)+(3*9)+(2*9)+(1*5)=133
133 % 10 = 3
So 42729-95-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H12O4S/c1-10(7,8)9-5-3-2-4-6/h6H,2-5H2,1H3
42729-95-3Relevant articles and documents
Application of Cp2TiCl-Promoted Radical-Induced Cyclization: An Expeditious Access to [ a]-Annelated Indoles
Khan, Hina P. A.,Chakraborty, Tushar Kanti
, p. 8000 - 8012 (2020)
An efficient and novel route for assembling pyrrolo/piperido[1,2-a]indoles is portrayed involving a radical-mediated reductive epoxide opening reaction of N-tethered epoxy-indoles that trigger facile intramolecular cyclization followed by an oxidative quenching step. Capitalizing on the operational simplicity of the method involving just two steps and use of an efficient C-C bond-forming reaction, this radical-based protocol enables the modular assembly of an important class of N-fused indole derivatives with versatile functional and structural diversity.
Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: Asymmetric synthesis and biological activities
Khiar, Noureddine,Werner, Sabine,Mallouk, Siham,Lieder, Franziska,Alcudia, Ana,Fernandez, Inmaculada
experimental part, p. 6002 - 6009 (2009/12/26)
(Chemical Equation Presented) A convergent and high-yielding approach for the asymmetric synthesis of sulforaphane 2 and four analogues differently substituted at the sulfinyl sulfur has been developed. The key step of the synthesis is the diastereoselect