- Method for synthesizing P-bromomethyl isobenzopropionic acid
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The invention provides a method for synthesizing p-bromomethyl isobenzopropionic acid, and relates to the technical field of organic synthesis. The synthesis method disclosed by the invention comprises the synthesis of isobenzoates. Vilsmeier Reagent preparation method comprises the following steps: synthesizing aldehyde isopropylparaben, synthesizing methyl isopropylbenzene, separating and purifying bromomethyl isobenzopropionic acid and, and the like. The final para-position selectivity of the method can reach 90 - 97%, and the three-waste yield is greatly reduced.
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Paragraph 0026; 0029-0030
(2021/10/27)
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- Visible-light-promoted site-specific and diverse functionalization of a c(sp3)-c(sp3) bond adjacent to an arene
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We report here a strategy for inert C-C bond functionalization. Site-specific cleavage and functionalization of a saturated C(sp3)-C(sp3) bond via a visible-light-induced radical process have been achieved. The general features of this reaction are as follows. (1) Both linear and cyclic C(sp3)-C(sp3) bonds with a vicinal arene can be specifically functionalized. (2) One carbon is converted into a ketone, and another can be tunably converted into nitrile, peroxide, or halide. (3) The typical conditions include 1.0 mol % of Ru(bpy)3Cl2, 1.0 or 5.0 equiv of Zhdankin reagent, white CFL (24 W), open flask, and room temperature. These reactions offer powerful tools to modify carbon skeletons that are intractable by conventional methods. Good selectivity and functional group tolerance, together with mild and open air conditions, make these transformations valuable and attractive.
- Fang, Fang,Liu, Zhong-Quan,Sun, Minzhi,Wang, Nengyong,Wang, Yaxin,You, Huichao,Zhao, Jianyou
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p. 6603 - 6612
(2020/07/27)
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- Conjugate addition of lithium enolates to aromatic carbonyl compounds complexed with aluminum tris(2, 6-diphenylphenoxide) (ATPH)
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Various lithium enolates of esters undergo effective 1, 6-addition to aromatic carbonyl compounds in the presence of aluminum tris(2, 6-diphenylphenoxide)(ATPH). Thieme.
- Saito, Susumu
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