Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A bottom-Up Approach
MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.
Paymode, Dinesh J.,Chang, Le,Chen, Dan,Wang, Binglin,Kashinath, Komirishetty,Gopalsamuthiram, Vijayagopal,McQuade, D. Tyler,Vasudevan,Ahmad, Saeed,Snead, David R.
supporting information
p. 5400 - 5404
(2021/07/26)
NOVEL COMPOUNDS AS GPR119 AGONISTS
The present invention relates to novel compounds of formula (I) as GPR119 agonist, composition compositions containing such compounds and method of preparation thereof.
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Paragraph 0577-0579
(2017/10/26)
NOVEL GPR119 AGONIST COMPOUNDS
The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.
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Paragraph 0445-0447
(2017/10/26)
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