436799-32-5 Usage
Description
2-Trifluoromethyl-5-bromopyridine is an organic compound that belongs to the pyridine family, characterized by the presence of a trifluoromethyl group at the 2nd position and a bromine atom at the 5th position. It is a white crystal powder known for its unique chemical properties, which make it a versatile building block in the synthesis of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
2-Trifluoromethyl-5-bromopyridine is used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Trifluoromethyl-5-bromopyridine is used as a key building block for the creation of novel agrochemicals, such as pesticides and herbicides, that target specific pests and weeds without harming the environment or human health.
Used in Organic Synthesis:
2-Trifluoromethyl-5-bromopyridine is utilized as a starting material in organic synthesis for the preparation of various heterocyclic compounds with potential applications in materials science, medicinal chemistry, and other fields.
Chemical Properties:
2-Trifluoromethyl-5-bromopyridine exhibits regioselective C-4 deprotonation with LDA (lithium diisopropylamide) and can be trapped with carbon dioxide to yield the corresponding C-4 acid. This property allows for further functionalization and modification of the molecule, expanding its potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 436799-32-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,6,7,9 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 436799-32:
(8*4)+(7*3)+(6*6)+(5*7)+(4*9)+(3*9)+(2*3)+(1*2)=195
195 % 10 = 5
So 436799-32-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrF3N/c7-4-1-2-5(11-3-4)6(8,9)10/h1-3H
436799-32-5Relevant articles and documents
Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A bottom-Up Approach
Paymode, Dinesh J.,Chang, Le,Chen, Dan,Wang, Binglin,Kashinath, Komirishetty,Gopalsamuthiram, Vijayagopal,McQuade, D. Tyler,Vasudevan,Ahmad, Saeed,Snead, David R.
supporting information, p. 5400 - 5404 (2021/07/26)
MMV390048 (1) is a clinical compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers.
NOVEL GPR119 AGONIST COMPOUNDS
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Paragraph 0445-0447, (2017/10/26)
The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.
