- Preparation method of 4-halogenated-3-fluorotoluene
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The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of 4-halogenated -3-fluorotoluene. The preparation reaction of 4-halogenated -3-fluorotolueneshown as a formula (I) is shown in the specification. According to the method, halogenation reaction is conducted on 3-fluorotoluene serving as an initial raw material to obtain a halide, and hydrogenreduction is conducted to obtain a compound shown in the general formula (I), wherein X is chlorine or bromine. According to the method, 3-fluorotoluene is used as a raw material, and a target product is obtained through two-step reactions of halogenation and reduction. The reaction steps in the process are few; diazotization, nitrification and other reactions are avoided, and the reaction safetyis high.
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- C?I-Selective Cross-Coupling Enabled by a Cationic Palladium Trimer
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While there is a growing interest in harnessing synergistic effects of more than one metal in catalysis, relatively little is known beyond bimetallic systems. This report describes the straightforward access to an air-stable Pd trimer and presents unambiguous reactivity data of its privileged capability to differentiate C?I over C?Br bonds in C?C bond formations (arylation and alkylation) of polyhalogenated arenes, which typical Pd0 and PdI-PdI catalysts fail to deliver. Experimental and computational reactivity data, including the first location of a transition state for bond activation by the trimer, are presented, supporting direct trimer reactivity to be feasible.
- Diehl, Claudia J.,Scattolin, Thomas,Englert, Ulli,Schoenebeck, Franziska
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supporting information
p. 211 - 215
(2018/12/13)
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- Syntheses of 4-methoxymethylbenzyl permethrinates containing fluorine and their insecticidal activity
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In order to investigate the relationship between the position of fluorine atom and insecticidal activity about 4-methoxymethylbenzyl permethrinates containing fluorine, 2 and 3-fluoro-4-methoxymethylbenzyl (±)-cis-permethrinate were synthesized. Their insecticidal activities were tested and the fluorine effect of title compounds was discussed.
- Zou, Xinzhuo,Qiu, Zongxing
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p. 173 - 179
(2007/10/03)
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