- Preparation method of distearoyl phosphatidylethanolamine
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The invention provides a preparation method of distearoyl phosphatidylethanolamine, wherein the preparation method comprises the following steps: (1) under alkaline conditions, carrying out amino protection reaction on glyceryl phosphatidylethanolamine represented by a formula (II) and a compound containing an amino protection group to obtain an intermediate a represented by a formula (III); (2) under the action of a catalyst, carrying out acylation reaction on the intermediate a and stearic anhydride to obtain an intermediate b represented by a formula (IV); and (3) under an acidic condition,carrying out an amino protection group removal reaction on the intermediate b to obtain distearoyl phosphatidylethanolamine represented by a formula (V), wherein R in the formula (III), the formula (IV) and the formula (V) represents an amino protection group. The preparation method is simple to operate, high in product yield and easy for industrial production.
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- New Phosphorylating Agents for the Synthesis of Phosphatidyl ethanolamines
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The preparation of three novel phosphorylating agents and their application toward the synthesis of phosphatidylethanolamines is described. These reagents are stable to air and moisture, and phosphorylate glycerols in good yield. The experimental procedures using these phosphorylating agents are simple. Moreover, the appropriate reagent can be selected based on the desired functional groups of the targeted phosphatidylethanolamine.
- Tsubaki, Kouta,Yamanaka, Tomoki,Hisamitsu, Takuya,Shimooka, Hirokazu,Kitamura, Mitsuru,Okauchi, Tatsuo
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p. 3827 - 3835
(2021/07/02)
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- Synthesis method for positive charge phospholipid
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The invention relates to a synthesis method for positive charge phospholipid. 1,2-Palmitodistearin is adopted as a raw material, and phospholipid DSPE is synthesized; then, lysine is connected to an amino of the DSPE; then, n beta-alanines are connected to two aminos of a BOC-lysine group in the product, finally, a salt is obtained, and a series of positive charge phospholipid is obtained.
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Paragraph 0066; 0077-0086
(2019/05/04)
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