4537-76-2

Basic information

• Product Name: 1,2-distearoylphosphatidylethanolamine
• Synonyms: 1,2-distearoylphosphatidylethanolamine;1-((((2-Aminoethoxy)hydroxyphosphinyl)oxy)methyl)-1,2-ethanediyl octadecanoate;Dc18pe;Distearoly-L-phosphatidylethanolamine;Octadecanoic acid, 1-((((2-aminoethoxy)hydroxyphosphinyl)oxy)methyl)-1,2-ethanediyl ester
• CAS NO: 4537-76-2
• Molecular Formula: C₄₁H₈₂NO₈P
• Molecular Weight: 748.065441
• Mol File: 4537-76-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-distearoylphosphatidylethanolamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-distearoylphosphatidylethanolamine(4537-76-2)
• EPA Substance Registry System: 1,2-distearoylphosphatidylethanolamine(4537-76-2)

Safety Data

• Hazardous Substances Data: 4537-76-2(Hazardous Substances Data)

Usage

Description

1,2-Distearoylphosphatidylethanolamine, also known as DSPE, is a type of phospholipid that consists of two stearoyl acyl groups attached to the phosphatidyl ethanolamine molecule. It is a significant component of biological membranes and plays a crucial role in various cellular functions.

Uses

Used in Pharmaceutical Industry:
1,2-Distearoylphosphatidylethanolamine is used as a key component in the formulation of liposomes for drug delivery. Its amphiphilic nature allows it to form stable lipid bilayers, which can encapsulate and protect therapeutic agents, enhancing their solubility, bioavailability, and targeted delivery to specific cells or tissues.
Used in Cosmetic Industry:
In the cosmetic industry, 1,2-Distearoylphosphatidylethanolamine is used as an emulsifying agent and skin conditioning agent. Its ability to form lipid bilayers helps in stabilizing emulsions and improving the texture and feel of cosmetic products. Additionally, it can help maintain the skin's natural barrier function and provide moisturizing effects.
Used in Food Industry:
1,2-Distearoylphosphatidylethanolamine is utilized as an ingredient in the food industry, particularly in the formulation of fat-based products such as spreads, creams, and sauces. Its emulsifying properties help in stabilizing mixtures and improving the overall texture and mouthfeel of these products.
Used in Nanotechnology:
DSPE is also employed in the development of nanoparticles for various applications, including drug delivery, imaging, and diagnostics. Its ability to form stable lipid bilayers makes it an ideal candidate for the construction of nanoscale structures with potential applications in medicine and biotechnology.

Upstream product

• 121075-80-7 3-(((benzyloxy)(2-(((benzyloxy)carbonyl)amino)ethoxy)phosphoryl)oxy)propane-1,2-diyl distearate 
• 64350-17-0 Octadecanoic acid 1-octadecanoyloxymethyl-2-{(2,2,2-trichloro-ethoxy)-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-ethyl ester 
• 64350-15-8 Octadecanoic acid 1-octadecanoyloxymethyl-2-[phenylamino-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-ethyl ester 
• 71260-71-4 Octadecanoic acid 2-[hydroxy-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-1-octadecanoyloxymethyl-ethyl ester 
• 51063-97-9 DL-α,β-distearin 
• 34813-39-3 α',β-Dilinolenoyl-N-phthaloyl-α-kephalin 
• 73068-91-4 1,2-Di-O-linolenoyl-sn-glycerin-3-O-phosphoryl-ethanolamin 
• 64350-19-2 N-Trityl O-(1,2-disteaoryl-sn-glycero-3-phosphoryl)-ethanolamin 
• 121010-32-0 phosphoric acid-(2-benzyloxycarbonylamino-ethyl ester)-(2,3-bis-stearoyloxy-propyl ester)-phenyl ester 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 57-11-4 stearic acid 
• 1190-00-7 2-aminoethyl 2,3-dihydroxypropyl hydrogen phosphate 
• 638-08-4 stearic anhydride 

Downstream Products

• 126695-59-8 4-(hydroxymethyl)-2,3,5,6-tetrafluorophenyl azide 

Relevant articles and documents

Synthesis of artificial group A and B substances.

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A general synthesis of glycerophospholipids.

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New Phosphorylating Agents for the Synthesis of Phosphatidyl ethanolamines

The preparation of three novel phosphorylating agents and their application toward the synthesis of phosphatidylethanolamines is described. These reagents are stable to air and moisture, and phosphorylate glycerols in good yield. The experimental procedures using these phosphorylating agents are simple. Moreover, the appropriate reagent can be selected based on the desired functional groups of the targeted phosphatidylethanolamine.