cas 454451-28-6, Boc-4-aminohexahydro-4h-azepine

Articles about 454451-28-6Total 3 be found

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Side chain SAR of bicyclic β-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712
The bridged monobactam β-lactamase inhibitor MK-8712 (1) effectively inhibits class C β-lactamases. Side chain N-alkylated and ring-opened analogs of 1 were prepared and evaluated for combination with imipenem to overcome class C β-lactamase mediated resi
Chen, Helen,Blizzard, Timothy A.,Kim, Seongkon,Wu, Jane,Young, Katherine,Park, Young-Whan,Ogawa, Aimie M.,Raghoobar, Susan,Painter, Ronald E.,Wisniewski, Doug,Hairston, Nichelle,Fitzgerald, Paula,Sharma, Nandini,Scapin, Giovanna,Lu, Jun,Hermes, Jeff,Hammond, Milton L.
p. 4267 - 4270
(2011/08/06)

NOVEL INHIBITORS OF BETA-LACTAMASE
A class of 7-oxo-2,6-diazabicyclo-[3.2.0]-heptane-6-sulfonic acid compounds substituted at the two position of the bicyclic ring with a heterocyclylaminocarbonyl group or a carbocyclylaminocarbonyl group are β-lactamase inhibitors. The compounds and their prodrugs and pharmaceutically acceptable salts are useful in the treatment of bacterial infections in combination with β-lactam antibiotics. In particular, the compounds are suitable for use with β-lactam antibiotics (e.g., imipenem and ceftazidime) against micro-organisms resistant to β-lactam antibiotics due to the presence of the β-lactamases.
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Page/Page column 42-44

(2008/06/13)

Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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(2008/06/13)

Chemical Properties

Boiling Point: 322.7 °C at 760 mmHg
Flash Point:149 °C
Density: 1.01 g/cm³
Storage Temp.:2-8°C
PKA: 12.51±0.20(Predicted)
PSA: 50.36000
LogP: 2.37290

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454451-28-6

Articles about 454451-28-6Total 3 be found

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Chemical Properties

Boiling Point: 322.7 °C at 760 mmHg

Flash Point:149 °C

Density: 1.01 g/cm³

Storage Temp.:2-8°C

PKA: 12.51±0.20(Predicted)

PSA: 50.36000

LogP: 2.37290

Global suppliers and manufacturers of 454451-28-6total 47 suppliers on LookChem

Article Database

454451-28-6

Articles about 454451-28-6Total 3 be found

More Articles about upstream products of 454451-28-6

Chemical Properties

Boiling Point: 322.7 °C at 760 mmHg

Flash Point:149 °C

Density: 1.01 g/cm3

Storage Temp.:2-8°C

PKA: 12.51±0.20(Predicted)

PSA: 50.36000

LogP: 2.37290

Global suppliers and manufacturers of 454451-28-6total 47 suppliers on LookChem

Density: 1.01 g/cm³