- Visible-Light- And PPh3-Mediated Direct C-N Coupling of Nitroarenes and Boronic Acids at Ambient Temperature
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We present here a metal-free, visible-light- and triphenylphosphine-mediated intermolecular, reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.
- Manna, Kartic,Ganguly, Tanusree,Baitalik, Sujoy,Jana, Ranjan
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supporting information
p. 8634 - 8639
(2021/11/01)
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- HISTONE DEMETHYLASE INHIBITORS
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The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
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Paragraph 00154; 00155; 00283
(2016/04/09)
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- Water-mediated catalyst preactivation: An efficient protocol for C-N cross-coupling reactions
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(Figure Presented) A protocol for forming a highly active Pd(O) catalyst from Pd(OAc)2, water, and biaryldialkylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides.
- Fors, Brett P.,Krattiger, Philipp,Strieter, Eric,Buchwald, Stephen L.
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supporting information; experimental part
p. 3505 - 3508
(2009/05/07)
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- A new general preparation of polyfunctional diarylamines by the addition of functionalized arylmagnesium compounds to nitroarenes
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The addition of functionalized arylmagnesium halides to nitroarenes in THF (-20 °C, 2 h) provides, after reductive workup (FeCl2, NaBH4), various polyfunctional diarylamines in 63-86% yield. Heterocyclic arylated amines can be prepar
- Sapountzis, Ioannis,Knochel, Paul
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p. 9390 - 9391
(2007/10/03)
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