458550-48-6

Basic information

• Product Name: N-(3-CYANOPHENYL)-N-(4-METHOXYPHENYL)AMINE
• Synonyms: N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine;Benzonitrile, 3-[(4-methoxyphenyl)amino]-
• CAS NO: 458550-48-6
• Molecular Formula: C14H12N2O
• Molecular Weight: 224.26
• Mol File: 458550-48-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 381.7°C at 760 mmHg
• Flash Point: 184.6°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 4.99E-06mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(3-CYANOPHENYL)-N-(4-METHOXYPHENYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-CYANOPHENYL)-N-(4-METHOXYPHENYL)AMINE(458550-48-6)
• EPA Substance Registry System: N-(3-CYANOPHENYL)-N-(4-METHOXYPHENYL)AMINE(458550-48-6)

Safety Data

• Hazardous Substances Data: 458550-48-6(Hazardous Substances Data)

Usage

General Description

N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine is a chemical compound with the molecular formula C15H13N3O. It is a derivative of aniline and is classified as an arylamine. N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine is mainly used as a building block in organic synthesis and pharmaceutical research. It has been reported to have potential uses in the development of pharmaceutical drugs, specifically in the treatment of diseases such as cancer and inflammation. However, due to its chemical properties and potential biological activities, it is important to handle and use N-(3-Cyanophenyl)-N-(4-methoxyphenyl)amine with care and in accordance with relevant safety guidelines.

InChI:InChI=1/C14H12N2O/c1-17-14-7-5-12(6-8-14)16-13-4-2-3-11(9-13)10-15/h2-9,16H,1H3

Upstream product

• 623-12-1 4-chloromethoxybenzene 
• 2237-30-1 m-cyanoaniline 
• 5720-07-0 4-methoxyphenylboronic acid 
• 619-24-9 3-nitrobenzonitrile 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Relevant articles and documents

Visible-Light- And PPh3-Mediated Direct C-N Coupling of Nitroarenes and Boronic Acids at Ambient Temperature

We present here a metal-free, visible-light- and triphenylphosphine-mediated intermolecular, reductive amination between nitroarenes and boronic acids at ambient temperature without any photocatalyst. Mechanistically, a slow reduction of nitroarenes to a nitroso and, finally, a nitrene intermediate occurs that leads to the amination product with concomitant 1,2-aryl/-alkyl migration from a boronate complex. A wide range of nitroarenes underwent C-N coupling with aryl-/alkylboronic acids providing high yields.

Water-mediated catalyst preactivation: An efficient protocol for C-N cross-coupling reactions

(Figure Presented) A protocol for forming a highly active Pd(O) catalyst from Pd(OAc)2, water, and biaryldialkylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides.