- MONOCARBOXYLIC ACID TRANSPORTER 4 (MCT4) MODULATORS AND USES THEREOF
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Disclosed herein are compounds, compositions, and methods for modulating the monocarboxylic acid transporter 4 (MCT4) with the compounds and compositions disclosed herein. Also described are methods of treating diseases or conditions that are mediated by
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Paragraph 0213-0214
(2021/11/26)
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- Taking diazo transfer to water: α-diazo carbonyl compounds from in situ generated mesyl azide
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Mesyl azide generated in situ in aqueous medium converted a range of active methylene substrates into the corresponding diazo compounds in good yields and high purity with no need for chromatographic purification. The products thus obtained are suitable for the subsequent RhII-catalyzed O–H insertions with no need for chromatography in the interim.
- Dar'in, Dmitry V.,Krasavin, Mikhail,Shevalev, Robert M.,Zhmurov, Petr A.
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p. 372 - 373
(2020/06/19)
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- THERAPEUTIC COMPOUNDS
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The present disclosure relates to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease.
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Paragraph 0422; 0423
(2017/11/07)
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- Bu4NI-Catalyzed α-Oxyacylation of Carbonyl Compounds with Toluene Derivatives
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A TBAI (tetrabutylammonium iodide)-catalyzed direct α-oxyacylation of carbonyl compounds from readily available toluene derivatives has been developed. The distinguished features of this metal-free protocol include the employment of simple starting material, a wide carbonyl compound scope, and mild reaction conditions.
- Li, Chengliang,Jin, Tao,Zhang, Xinglu,Li, Chunju,Jia, Xueshun,Li, Jian
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supporting information
p. 1916 - 1919
(2016/05/19)
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- METHOD FOR PRODUCING ALPHA-ACYLOXYCARBONYL COMPOUND AND NOVEL ALPHA-ACYLOXYCARBONYL COMPOUND
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A method for producing an α-acyloxycarbonyl compound of the present invention includes performing an intermolecular reaction between a carboxylic acid and a carbonyl compound selected from the group consisting of ketones, aldehydes, and esters, which have
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Page/Page column 7
(2013/02/27)
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- In situ generated (Hypo)iodite catalysts for the direct α-oxyacylation of carbonyl compounds with carboxylic acids
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It′s the iodine: The intra- and intermolecular title reaction is catalyzed by an in situ generated ammonium (hypo)iodite species. Either H 2O2 or tert-butyl hydroperoxide (TBHP) can be used as an environmentally benign oxidant and a wide range of substrates react to give the corresponding α-acyloxycarbonyl compounds in good to excellent yields.
- Uyanik, Muhammet,Suzuki, Daisuke,Yasui, Takeshi,Ishihara, Kazuaki
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supporting information; experimental part
p. 5331 - 5334
(2011/07/08)
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- PYRIDIN-2-YL-AMINO-1,2,4-THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS
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Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein
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Page/Page column 113; 116; 119-120
(2009/05/29)
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- Synthesis of functionalized p-dihydrobenzoquinones and p-benzoquinones based on [3+3] cyclizations of 1,3-bis-silyl enol ethers
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Functionalized mono-protected p-dihydrobenzoquinones were prepared by [3+3] cyclization of 1,3-bis-silyl enol ethers with 2-acyloxy-3-(silyloxy)alk-2-en-1-ones. Deprotection and oxidation of the products afforded the corresponding p-benzoquinones.
- Ahmed, Zafar,Fischer, Christine,Spannenberg, Anke,Langer, Peter
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p. 4800 - 4806
(2007/10/03)
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- The Effect of Ring Nitrogen Atoms on the Homolytic Reactivity of Phenolic Compounds: Understanding the Radical-Scavenging Ability of 5-Pyrimidinols
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Six substituted 5-pyrimidinols were synthesized, and the thermochemistry and kinetics of their reactions with free radicals were studied and compared to those of equivalently substituted phenols. To assess their potential as hydrogen-atom donors to free r
- Valgimigli, Luca,Brigati, Giovanni,Pedulli, Gian Franco,DiLabio, Gino A.,Mastragostino, Marina,Arbizzani, Catia,Pratt, Derek A.
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p. 4997 - 5010
(2007/10/03)
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- Novel chain-breaking antioxidants
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Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs.
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- Reactions of copper(II) β-diketonates under free radical conditions. Preparation of highly congested β-diketones
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Copper(II) β-diketonates react with alkyl bromides under free radical conditions to give highly congested β-diketones such as 3-(1-adamantyl)-3-alkylpentane-2,4-diones. Another typical free radical reagent: benzoyl peroxide, reacts also functionalizing the intercarbonyl positions.
- Lloris, Maria E.,Galvez, Nicanor,Marquet, Jorge,Moreno-Manas, Marcial
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p. 8031 - 8042
(2007/10/02)
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