- NOVEL CYTOTOXIC AGENTS FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULE
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Provided are cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
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Page/Page column 82
(2015/03/16)
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- Selective two-phase-hydrogenation of sorbic acid with novel water soluble ruthenium complexes
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Neutral and cationic water soluble Cp*-ruthenium-complexes of the type [Cp*Ru(CO)Cl(PR3)] and [Cp*Ru(CO)(PR3)]CF3SO3 (R=CH2OH, (CH2)3OH, Ph-m-SO3Na) have been synthesized for the first time and have been used as catalysts in two-phase-hydrogenations. The neutral complexes have been fully characterized. But the cationic complexes which have not been isolated are effective catalysts for the selective hydrogenation of sorbic acid in water/n-heptane leading to the formation of cis-3-hexenoic acid and trans-3-hexenoic acid.
- Driessen-Hoelscher, Birgit,Heinen, Joerg
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p. 141 - 146
(2007/10/03)
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