4706-17-6 Usage
Description
TRIS(HYDROXYPROPYL)PHOSPHINE, also known as THPP, is an organic compound with the chemical formula C9H21O3P. It is a colorless to pale yellow liquid and is known for its reducing properties. THPP is widely used in various applications due to its ability to cleave disulfide bonds and act as a ligand in the synthesis of dendritic macromolecules.
Uses
Used in Pharmaceutical Industry:
TRIS(HYDROXYPROPYL)PHOSPHINE is used as a reducing agent for the cleavage of disulfide bonds in both aqueous and buffered aqueous-organic medium. This application is crucial in the development and synthesis of various pharmaceutical compounds, as disulfide bonds play a significant role in the structure and stability of proteins and peptides.
Used in Chemical Synthesis:
TRIS(HYDROXYPROPYL)PHOSPHINE is used as a ligand in the synthesis of dendritic macromolecules, which are used as catalysts in heterogenizing homogeneous reactions. Dendritic macromolecules are highly branched structures that have a wide range of applications in catalysis, drug delivery, and sensing due to their unique properties and ability to accommodate multiple functional groups.
Used in Peptide Synthesis:
TRIS(HYDROXYPROPYL)PHOSPHINE is used as a reducing agent for the synthesis of disulfide cyclopeptides via one-pot peptide ligation-oxidative cyclization. This application is essential in the development of cyclic peptides, which have a wide range of biological activities and are used in various therapeutic applications, including antibiotics, antifungals, and anticancer agents.
Check Digit Verification of cas no
The CAS Registry Mumber 4706-17-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,0 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4706-17:
(6*4)+(5*7)+(4*0)+(3*6)+(2*1)+(1*7)=86
86 % 10 = 6
So 4706-17-6 is a valid CAS Registry Number.
4706-17-6Relevant articles and documents
NOVEL CYTOTOXIC AGENTS FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULE
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Page/Page column 82, (2015/03/16)
Provided are cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.