29269-17-8 Usage
General Description
3-[BIS-(2-METHOXYCARBONYL-ETHYL)-PHOSPHANYL]-PROPIONIC ACID METHYL ESTER is a chemical compound consisting of a propionic acid moiety with a methyl ester group and two bis(2-methoxycarbonyl-ethyl)phosphanyl groups attached. It is commonly used as a reagent in organic synthesis and as a phosphorus source in the production of phosphine ligands for catalysis. 3-[BIS-(2-METHOXYCARBONYL-ETHYL)-PHOSPHANYL]-PROPIONIC ACID METHYL ESTER has been studied for its potential use in the development of novel materials, pharmaceuticals, and biologically active substances. Its structure and properties make it a versatile building block for the synthesis of various organic and inorganic compounds with potential applications in a wide range of fields.
Check Digit Verification of cas no
The CAS Registry Mumber 29269-17-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,2,6 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 29269-17:
(7*2)+(6*9)+(5*2)+(4*6)+(3*9)+(2*1)+(1*7)=138
138 % 10 = 8
So 29269-17-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H21O6P/c1-16-10(13)4-7-19(8-5-11(14)17-2)9-6-12(15)18-3/h4-9H2,1-3H3
29269-17-8Relevant articles and documents
A Chemical Probe for Protein Crotonylation
Bos, Jeffrey,Muir, Tom W.
supporting information, p. 4757 - 4760 (2018/04/16)
Protein lysine crotonylation has emerged as an important post-translational modification (PTM) in the regulation of gene transcription through epigenetic mechanisms. Here we introduce a chemical probe, based on a water-soluble phosphine warhead, which reacts with the crotonyl modification. We show that this reagent is complementary to antibody-based tools allowing detection of endogenous cellular proteins such as histones carrying the crotonylation PTM. The tool is also used to show that the histone acylation activity of the transcriptional coactivator, p300, can be activated by pre-existing lysine crotonylation through a positive feedback mechanism. This reagent provides a versatile and sensitive probe for the analysis of this PTM.
