3-[BIS-(2-METHOXYCARBONYL-ETHYL)-PHOSPHANYL]-PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-[BIS-(2-METHOXYCARBONYL-ETHYL)-PHOSPHANYL]-PROPIONIC ACID METHYL ESTER
• CAS No.: 29269-17-8
• Molecular Formula: C12H21 O6 P
• Molecular Weight: 292.269
• Hs Code.: 2915900090
• Mol file: 29269-17-8.mol

Synonyms:Propanoicacid, 3,3',3''-phosphinidynetris-, trimethyl ester (9CI); Propionic acid,3,3',3''-phosphinidynetri-, trimethyl ester (8CI);Tris[2-(methoxycarbonyl)ethyl]phosphine

Chemical Property of 3-[BIS-(2-METHOXYCARBONYL-ETHYL)-PHOSPHANYL]-PROPIONIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 1.57E-05mmHg at 25°C
• Boiling Point: 365.4°C at 760 mmHg
• Flash Point: 174.8°C
• PSA: 92.49000
• LogP: 1.15760
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Trimethyl3,3',3''-phosphinetriyltripropanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[BIS-(2-METHOXYCARBONYL-ETHYL)-PHOSPHANYL]-PROPIONIC ACID METHYL ESTER

There total 1 articles about 3-[BIS-(2-METHOXYCARBONYL-ETHYL)-PHOSPHANYL]-PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

methanol (67-56-1) + tris(2-carboxyethyl)phosphine (5961-85-3) → trimethyl 3,3',3''-phosphinetriyltripropanoate (29269-17-8)

Guidance literature:

With Amberlyst 15 hydrogen form; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jacs.7b13141

Reference yield:

trimethyl 3,3',3''-phosphinetriyltripropanoate (29269-17-8) → tris(3-hydroxypropyl)phosphine (4706-17-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h;

Reference yield:

trimethyl 3,3',3''-phosphinetriyltripropanoate (29269-17-8) → ((3-(methylsulfinothioyl)propyl)phosphoryl)bis(propane-3,1-diyl) bis(4-methylbenzenesulfonate)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

2.1: acetic acid; dihydrogen peroxide / water

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: sodium hydroxide / methanol; water / 1 h / 4 - 20 °C

4.2: 4 h

5.1: pyridine / dichloromethane / 6 h / 20 °C

With pyridine; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; dihydrogen peroxide; acetic acid; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

methanol

tris(2-carboxyethyl)phosphine

Downstream raw materials:

tris(3-hydroxypropyl)phosphane oxide

tris(3-hydroxypropyl)phosphine

Refernces