Nucleic acid related compounds. 91. Biomimetic reactions are in harmony with loss of 2'-substituents as free radicals (not anions) during mechanism-based inactivation of ribonucleotide reductases. Differential interactions of azide, halogen, and alkylthio
The initial step in the mechanism-based inactivation of ribonucleotide reductases by 2'-chloro-2'deoxynucleotides is abstraction of H3' by a proximal free radical on the enzyme. The C3' radical is postulated to undergo spontaneous loss of chloride, and th
Robins, Morris J.,Wnuk, Stanislaw F.,Hernández-Thirring, Amelia E.,Samano, Mirna C.
p. 11341 - 11348
(2007/10/03)
A Convenient Synthesis of 2'-Deoxyuridine
Reaction of uridine (2) with 2-acetoxybenzoyl bromide (10) furnishes 3',5'-di-O-acetyl-2'-bromo-2'-deoxyuridine (4).Reaction of 2 with 2-acetoxy-5-nitrobenzoyl chloride (11) furnishes 3',5'-di-O-acetyl-2'-chloro-2'-deoxyuridine (5).The transformation of 4 and 5 to 2'-deoxyuridine (1) is known .
Bhat, K. S.,Rao, A. S.
p. 678 - 679
(2007/10/02)
21-[82Br]-bromo-21-deoxyuridine for tumor uptake studies
-
Lee,Knaus,Wiebe
p. 167 - 168
(2007/10/09)
More Articles about upstream products of 4753-02-0