- Anthraquinones from Neonauclea calycina and their inhibitory activity against DNA topoisomerase II
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In a series of searches for DNA topoisomerase II inhibitors from naturally occurring compounds, a wood extract of Neonauclea calycina MERR. (Rubiaceae) showed a moderate effect in vitro. Purification of the extract resulted in the isolation of seven known anthraquinones. The structures were characterized as damnacanthal, rubindin 1-methyl ether, nordamnacanthal, morindone, damnacanthol, lucidin 3-O-primeveroside and morindone 6-O- primeveroside by spectral analysis, respectively. Damnacanthal and morindone showed an intensive inhibitory effect against topoisomerase II (IC50: 20 μg/ml and 21 μg/ml).
- Tosa, Hideki,Iinuma, Munekazu,Asai, Fujio,Tanaka, Toshiyuki,Nozaki, Hiroshi,Ikeda, Shougo,Tsutsui, Ken,Tsutsui, Kimiko,Yamada, Masashi,Fujimori, Shiho
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p. 641 - 642
(2007/10/03)
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