Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis
Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme-catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). I
Nam, Tae-Gyu,Nara, Susheel J.,Zagol-Ikapitte, Irene,Cooper, Thomas,Valgimigli, Luca,Oates, John A.,Porter, Ned A.,Boutaud, Olivier,Pratt, Derek A.
scheme or table
p. 5103 - 5112
(2010/04/04)
DIPHENYL SUBSTITUTED CYCLOALKANES
The present invention provides compounds of Formula I which are FLAP inhibitors useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
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Page/Page column 61
(2009/05/28)
A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants
(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.
Nara, Susheel J.,Jha, Mukund,Brinkhorst, Johan,Zemanek, Tony J.,Pratt, Derek A.
supporting information; experimental part
p. 9326 - 9333
(2009/04/06)
INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP)
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Page/Page column 49
(2008/06/13)
DIPHENYL SUBSTITUTED ALKANES
The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
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Page/Page column 66
(2009/01/23)
DIARYL SUBSTITUTED ALKANES
The instant invention provides compounds of Formula (II) which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (II) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
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Page/Page column 52
(2008/06/13)
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