- PIPERAZINE DERIVATIVES WHICH EXHIBIT ACTIVITY AS SEROTONIN AND NORADRENALINE RE-UPATKE INHIBITORS
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A compound of formula (I), wherein R1 is H; R2 is aryl, het, C3-8cycloalkyl, C1-6alkyl, (CH2)zaryl or R4, wherein each of the cycloalkyl, aryl, het and R4 groups is op
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Page/Page column 54; 55
(2010/02/13)
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- 2,2'-Dimethoxybibenzyl
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The 2,2'-dimethoxybibenzyl molecule, C16H18O2, has the midpoint of the -CH2-CH2- bond on an inversion centre.Each benzene ring deviates slightly from planarity, shows marked angular distortion and is inclined at 81.5(1) deg to the plane of the C(Ar)-CH2-CH2-moiety.
- Ross, Jennifer-Nicola,Wardell, James,Ferguson, George,Low, John N.
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p. 976 - 977
(2007/10/02)
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- CYCLISATION DE DIARYLALCANES EN MILIEU SUPERACIDE: SYNTHESE DE CETONES TRICYCLIQUES A METHYLE ANGULAIRE ET MECANISME DE LEUR ISOMERISATION
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Cyclisation of redily available diaryl-1,2 ethanes 1-4 proceeds in SbF5-HF at 0oC to yield tricyclic phenantrenones 5,6,7 and 11 bearing an angular methyl group.This process implies the electrophilic attack of the more basic aromatic ring, reacting through its disprotonated form (on the oxygen and the meta carbon atom) on the second aromatic ring.Isomerization of these primary products may be observed (to give ketones 8,9,10 from 3 and 12 from 4) and it has been demonstrated by the use of specifically deuterated 3d that it involves stereospecific 1,2 hydride (or deuteride) shifts, without exchange.
- Berrier, C.,Jacquesy, J. C.,Gesson, J. P.,Renoux, A.
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p. 1983 - 1994
(2007/10/02)
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