- Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2
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The synthesis of (2RS)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and its enantiomers, analogs of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol ((RS)-9) is described. Compounds were tested for electrographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for α1-, α2- and β1-adrenoceptors binding affinities. The antagonist potency of the new compounds was compared with carvedilol and (RS)-9.
- Groszek, Grazyna,Nowak-Krol, Agnieszka,Wdowik, Tomasz,Swierczynski, Dariusz,Bednarski, Marek,Otto, Monika,Walczak, Maria,Filipek, Barbara
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experimental part
p. 5103 - 5111
(2010/02/28)
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- Antimicrobial indolequinones from the mid-intestinal gland of the muricid gastropod Drupella fragum
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Three new indolequinones, 6-methoxyindole-4,7-quinone (1), 5- methoxyindole-4,7-quinone (2) and 5-methylindole-4,7-quinone (3) were isolated from the mid-intestinal gland of the muricid gastropod Drupella fragum. The structures of 1 and 2 were established
- Fukuyama, Yoshiyasu,Iwatsuki, Chie,Kodama, Mitsuaki,Ochi, Masamitsu,Kataoka, Kumi,Shibata, Kozo
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p. 10007 - 10016
(2007/10/03)
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- Product based on inorganic or organic lamellar particles, containing a melanotic pigment, process for preparing it and its use in cosmetics
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The invention relates to a product in powder form consisting of organic or inorganic particles having a lamellar structure, having a size of less than 50 microns and containing at least one synthetic melanotic pigment formed in situ by oxidation of an indole compound, and to its use for the protection of the human epidermis, in make-up products and for dyeing hair.
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- Use of indole derivative for dyeing keratin materials, tinctorial compositions, new compounds and dyeing process
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Process for dyeing keratin fibers by using derivatives of formula: STR1 where: R1 =H, lower alkyl or SiR11 R12 R13 ; R2 and R3, which may be identical or different, =H, alkyl, carboxyl, alkoxycarbonyl or --COOSiR11 R12 R13 ; R4 to R7, which may be identical or different, =H or an O--Z group, where Z=H, C1 -C20 alkyl, aralkyl, formyl, C2 -C20 acyl, C3 -C20 alkenyl, --SiR11 R12 R13, --P(O)(OR8)2, R8 OSO2 ; or a heterocycle which may contain a P(O)(OR8) or CR9 R10 group; with the reservation that at least two of R4 to R7 denotes OZ or form a ring, and that at least one of R4 or R7 represents OZ; R8 and R9 =H, lower alkyl; R10 =alkoxy, mono- or dialkylamino; R11, R12 and R13, which may be identical or different, are alkyl groups; or their alkali metal, alkaline-earth metal, ammonium and amine salts.
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- Process for dyeing keratinous fibres with a hydroxyindole in combination with a quinone derivative; and novel 1,4-benzoquinones
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Process for dyeing keratinous fibres, comprising the step of applying to these fibres at least one composition A containing, in a medium appropriate for dyeing, at least one mono- or di-hydroxyindole the application of the composition A being preceded or followed by the application of a composition B containing, in a medium appropriate for dyeing, at least one quinone derivative chosen from ortho- or para-benzoquinones, monoimines or diimines of ortho- or para-benzoquinones, 1,2- or 1,4-naphthoquinones, sulphonimides of ortho- or para-benzoquinones, α, ω-alkylene-bis-1,4-benzoquinones, or 1,2- or 1,4-naphthoquinone-monoimines or -diimines; the mono- or di-hydroxyindoles and the quinone derivatives being chosen such that the oxidation-reduction potential difference ΔE between the oxidation-reduction potential Ei of the mono- or di-hydroxyindoles, determined at pH 7 in a phosphate medium on a vitreous carbon electrode by voltametry, and the oxidation-reduction potential Eq of the quinone derivative determined at pH 7 in a phosphate medium by polarography on a mercury electrode and relative to a saturated calomel electrode is such that
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