49635-16-7

Basic information

• Product Name: 1H-Indol-4-ol, 5-Methoxy-
• Synonyms: 1H-Indol-4-ol, 5-Methoxy-;4-Hydroxy-5-Methoxy-indole;5-Methoxy-1H-indol-4-ol
• CAS NO: 49635-16-7
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.17326
• Mol File: 49635-16-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 152-154 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
• Boiling Point: 359.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.312±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.22±0.50(Predicted)
• CAS DataBase Reference: 1H-Indol-4-ol, 5-Methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indol-4-ol, 5-Methoxy-(49635-16-7)
• EPA Substance Registry System: 1H-Indol-4-ol, 5-Methoxy-(49635-16-7)

Safety Data

• Hazardous Substances Data: 49635-16-7(Hazardous Substances Data)

Usage

General Description

1H-Indol-4-ol, 5-methoxy- is a chemical compound with the molecular formula C10H11NO2. It is an indole derivative with a methoxy group attached to the 5 position of the indole ring. 1H-Indol-4-ol, 5-methoxy- is commonly found in various natural products and is also used in the synthesis of pharmaceuticals and other organic compounds. It exhibits a range of pharmacological properties, including anti-inflammatory, analgesic, and serotonin receptor agonist activities. It is also involved in the biosynthesis of various alkaloids and is an important building block in organic chemistry.

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Relevant articles and documents

Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2

The synthesis of (2RS)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and its enantiomers, analogs of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol ((RS)-9) is described. Compounds were tested for electrographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for α1-, α2- and β1-adrenoceptors binding affinities. The antagonist potency of the new compounds was compared with carvedilol and (RS)-9.

Product based on inorganic or organic lamellar particles, containing a melanotic pigment, process for preparing it and its use in cosmetics

The invention relates to a product in powder form consisting of organic or inorganic particles having a lamellar structure, having a size of less than 50 microns and containing at least one synthetic melanotic pigment formed in situ by oxidation of an indole compound, and to its use for the protection of the human epidermis, in make-up products and for dyeing hair.

Process for dyeing keratinous fibres with a hydroxyindole in combination with a quinone derivative; and novel 1,4-benzoquinones

Process for dyeing keratinous fibres, comprising the step of applying to these fibres at least one composition A containing, in a medium appropriate for dyeing, at least one mono- or di-hydroxyindole the application of the composition A being preceded or followed by the application of a composition B containing, in a medium appropriate for dyeing, at least one quinone derivative chosen from ortho- or para-benzoquinones, monoimines or diimines of ortho- or para-benzoquinones, 1,2- or 1,4-naphthoquinones, sulphonimides of ortho- or para-benzoquinones, α, ω-alkylene-bis-1,4-benzoquinones, or 1,2- or 1,4-naphthoquinone-monoimines or -diimines; the mono- or di-hydroxyindoles and the quinone derivatives being chosen such that the oxidation-reduction potential difference ΔE between the oxidation-reduction potential Ei of the mono- or di-hydroxyindoles, determined at pH 7 in a phosphate medium on a vitreous carbon electrode by voltametry, and the oxidation-reduction potential Eq of the quinone derivative determined at pH 7 in a phosphate medium by polarography on a mercury electrode and relative to a saturated calomel electrode is such that