- Pyrrolo[2,1-c][1,4]naphthodiazepine Linked Piperazine Compounds and a Process for the Preparation Thereof
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The present invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R′=(Formula II). n=1-9 and R″=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl
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Paragraph 0271
(2013/12/04)
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- Oxidative cleavage of lactams in water using dioxiranes: An expedient and environmentally-safe route to ω-nitro acids
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By taking advantage of the appreciable stability of dioxiranes in water, a safe yet efficient route to ω-nitro acids by oxidation of lactams of various ring sizes under mild conditions has been reported. In essentially all the cases examined, reactions proceed selectively to afford products in remarkably high yields (up to 99%) and with high purity (94-99%). Also, an interesting example of higher reaction selectivity in water than in organic solvent (acetonitrile) is discussed.
- Annese, Cosimo,D'Accolti, Lucia,Filardi, Rosella,Tommasi, Immacolata,Fusco, Caterina
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p. 515 - 517
(2013/02/23)
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- PYRROLO [2,1-C]1,4]NAPHTHODIAZEPINE LINKED PIPERAZINE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF
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The present invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R= R'= (Formula II). n=1-9 and R''= methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl
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Page/Page column 42
(2012/09/10)
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- NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF
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The present invention relates to oligomer compounds, including dimers and trimers, formed by a disulfide, sulfinyl thio, olefin or hydrocarbon bond, or a hydrazone exchange bond between two or more monomers. Methods of making the monomers and the oligomers is also disclosed. Use of the compounds for inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-1 RNA frameshifting stem-loop and a (CUG)n expanded repeat stem- loop are disclosed, as are methods of treating diseases associated with these target RNA molecules.
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Page/Page column 45-46
(2012/07/14)
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- Synthesis of 3-nitropropanol homologues
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Several high yielding routes to oxygenated nitropropanes have been developed that include a palladium catalyzed nitro allylation of allylic carbonates, nitration of brominated compounds and a nitro aldol condensation/hydrogenation sequence. Georg Thieme Verlag Stuttgart.
- Addo, James K.,Teesdale-Spittle, Paul,Hoberg, John O.
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p. 1923 - 1925
(2007/10/03)
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- Arylmethyl radicals from arylmethoxybromodiazirines
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(Chemical Equation Presented) Photolytic decompositions of 3-arylmethoxy-3-bromodiazirines afford arylmethyl radicals by homolyses of the diazirines' excited states.
- Moss, Robert A.,Fu, Xiaolin
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p. 3353 - 3356
(2007/10/03)
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- An expeditious synthesis of 3-nitropropionic acid and its ethyl and methyl esters
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The synthesis to 3-nitropropionic acid 1 was easily accomplished, in two steps, from commercially available acrolein in 60% yield. The ethyl and methyl esters of 1 were also obtained.
- Silva,Costa,Pereira
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p. 595 - 600
(2007/10/03)
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- The Fungal Biosynthesos of 3-Nitropropionic Acid: Is the Decarboxylation of L-Nitrosuccinate an Enzymatic Reaction?
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In vitro enzymatic hydrolysis of diethyl (RS)-nitrosuccinate 2c by pig liver esterase at pH 7.8 affords 3-nitropropionic acid 1 indicating that the decarboxylation of (RS)-nitrosuccinate 2b is spontaneous under physiological conditions.In the in vivo synthesis of 1 from L-aspartate by cells of Penicillium atrovenetum, which involves oxidation of L-aspartate to nitrosuccinic acid, the decarboxylation of the nitrosuccinate may not require a specific biological catalyst.
- Baxter, Robert L.,Smith, Shona L.,Martin, Jennifer R.,Hanley, A. Bryan
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p. 2297 - 2300
(2007/10/02)
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