504-88-1 Usage
Description
3-Nitropropionic acid (3-NPA) is a gold crystalline solid, known for its chemical properties and various applications in different fields. It is a compound with the chemical formula C3H5NO4, and it appears as golden crystals when derived from chloroform.
Uses
Used in Pharmaceutical Industry:
3-Nitropropionic acid is used as an antineoplastic agent for its potential role in cancer treatment. It has been found to have effects on various types of cancer, making it a valuable compound for pharmaceutical research and development.
Used in Neuroscience Research:
3-Nitropropionic acid is used as a tool to generate multiple system atrophy-parkinsonism (MSA-P) models in rats. This helps researchers evaluate the effects of 3-NPA on embryonic striatal and mesencephalic grafts, which are crucial for understanding the underlying mechanisms of neurodegenerative diseases.
Used in Neurochemical Studies:
3-Nitropropionic acid is used to inject into the nigrostriatal dopaminergic pathway in rats. This application allows researchers to examine the specific effects of 3-NPA on the dopamine system, which is essential for studying the role of dopamine in various neurological conditions.
Used in Cellular and Molecular Biology:
3-Nitropropionic acid serves as a succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines. This application is vital for understanding the role of SDH in cellular respiration and energy production, as well as its potential implications in various diseases and disorders.
Air & Water Reactions
Water soluble.
Reactivity Profile
3-NITROPROPIONIC ACID is incompatible with bases, oxidizing agents and reducing agents.
Fire Hazard
Flash point data for 3-NITROPROPIONIC ACID are not available; however, 3-NITROPROPIONIC ACID is probably combustible.
Biological Activity
3-nitropropionic acid is an irreversible inhibitor of mitochondrial respiratory complex ii (succinate dehydrogenase), which impairs cellular energy metabolism by inhibiting succinate dehydrogenase and reducing atp production. also, 3-nitropropionic acid can cause the generation and release of reactive oxygen species (ros) from mitochondria (the main source of cellular oxidative stress), mitochondrial dna damage, as well as loss of mitochondrial function.1. huang ls, sun g, cobessi d, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex ii, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. journal of biological chemistry, 2006, 281(9): 5965-5972.2. zhang jq, shen m, zhu cc, et al. 3-nitropropionic acid induces ovarian oxidative stress and impairs follicle in mouse. plos one, 2014, 9(2): e86589.3. mandavilli bs, boldogh i, van houten b. 3-nitropropionic acid-induced hydrogen peroxide, mitochondrial dna damage, and cell death are attenuated by bcl-2 overexpression in pc12 cells. brain research. molecular brain research, 2005, 133(2): 215-223.
Biochem/physiol Actions
Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.
Safety Profile
Poison by intravenous andintraperitoneal routes. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.
Check Digit Verification of cas no
The CAS Registry Mumber 504-88-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 504-88:
(5*5)+(4*0)+(3*4)+(2*8)+(1*8)=61
61 % 10 = 1
So 504-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)/p-1
504-88-1Relevant articles and documents
Pyrrolo[2,1-c][1,4]naphthodiazepine Linked Piperazine Compounds and a Process for the Preparation Thereof
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Paragraph 0271, (2013/12/04)
The present invention provides a compound of general formula A, useful as potential antitumour agents against five human cancer cell lines. The present invention further provides a process for the preparation of pyrrolo[2,1-c][1,4]naphthodiazepine linked substituted piperazine conjugates attached through different alkane spacers of general formula A. (Formula I) General formula A. Where R=R′=(Formula II). n=1-9 and R″=methyl, ethyl, acetyl, benzyl, piperinoyl, 4-fluorophenyl, 4-chlorophenyl, 4-methoxyphenyl, pyridyl, pyrimidyl
NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF
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Page/Page column 45-46, (2012/07/14)
The present invention relates to oligomer compounds, including dimers and trimers, formed by a disulfide, sulfinyl thio, olefin or hydrocarbon bond, or a hydrazone exchange bond between two or more monomers. Methods of making the monomers and the oligomers is also disclosed. Use of the compounds for inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-1 RNA frameshifting stem-loop and a (CUG)n expanded repeat stem- loop are disclosed, as are methods of treating diseases associated with these target RNA molecules.
