PREPARATION OF 2-ALKYL- AND 2-ARYL-5-AMINO-4-CYANO-1,3-OXAZOLES
Aminopropanedinitrile p-toluenesulfonate (aminomalonitrile tosylate, AMNT) reacts with acid chlorides to give 2-alkyl- and 2-aryl-5-amino-4-cyano-1,3-oxazoles in good to excellent yields.
Synthesis and heterocyclization of 5-amino-4-cyano-1, 3-oxazoles
A convenient one-pot method for synthesis of some new oxazolo[5,4-d] pyrimidines via base catalyzed heterocyclization of 2-substituted 5-amino-4-cyano-1,3-oxazoles with various isothiocyanates is described.