Total synthesis of the spiroketal macrolide (+) milbemycin α1
The total synthesis of the antiparasitic spiroketal macrolide (+) milbemycin α1 is reported, following Julia sulfone anion coupling of the sulfone 3 with a northern hemisphere aldehyde 2 and subsequent functional group elaboration.
Ley, Steven V.,Madin, Andrew,Monck, Nathaniel J. T.