51596-10-2 Usage
Description
Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin A3 is used as a nematocide and insecticide. The acaricidal and nematocidal activity of a mixture of milbemycin A3 and milbemycin A4 against adult spider mites, spider mite eggs, and C. elegans are reported at IC50 values of 5.3, 41.1, and 9.5 μg/ml.
Uses
Different sources of media describe the Uses of 51596-10-2 differently. You can refer to the following data:
1. Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A3 is a major member of a group of analogues containing a 25-methyl substituent. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels.
2. Milbemycin A3 is widely used as a pesticides in agriculture. Milbemycin A3 (Milbemycin EP Impurity B) is an antibiotic with acaricidal activity.
Check Digit Verification of cas no
The CAS Registry Mumber 51596-10-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,9 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 51596-10:
(7*5)+(6*1)+(5*5)+(4*9)+(3*6)+(2*1)+(1*0)=122
122 % 10 = 2
So 51596-10-2 is a valid CAS Registry Number.
51596-10-2Relevant articles and documents
Total synthesis of the spiroketal macrolide (+) milbemycin α1
Ley, Steven V.,Madin, Andrew,Monck, Nathaniel J. T.
, p. 7479 - 7482 (1993)
The total synthesis of the antiparasitic spiroketal macrolide (+) milbemycin α1 is reported, following Julia sulfone anion coupling of the sulfone 3 with a northern hemisphere aldehyde 2 and subsequent functional group elaboration.
