51596-12-4 Usage
Description
(6R,25R)-28-Deoxy-6,28-epoxy-25-methylmilbemycin B is a chemical compound belonging to the milbemycin class, which is characterized by its unique 28-deoxy-6,28-epoxy-25-methyl substitution on the milbemycin B backbone. (6R,25R)-28-Deoxy-6,28-epoxy-25-methylmilbemycin B is known for its potent activity against a range of parasites, including nematodes, mites, and insects, making it a valuable asset in veterinary medicine and pest control.
Uses
Used in Veterinary Medicine:
(6R,25R)-28-Deoxy-6,28-epoxy-25-methylmilbemycin B is used as an anthelmintic, insecticidal, and acaricidal agent for the control and treatment of parasitic infestations in livestock and companion animals. Its potent activity against various parasites contributes to its effectiveness in maintaining the health and well-being of animals.
Used in Pest Control:
In the field of pest control, (6R,25R)-28-Deoxy-6,28-epoxy-25-methylmilbemycin B is used as an insecticidal and acaricidal agent to manage and control insect and mite populations that can cause damage to crops and other plants. Its effectiveness in targeting a broad spectrum of pests makes it a useful tool in integrated pest management strategies.
Used in Research and Development:
Due to its complex chemical structure and biological activity, (6R,25R)-28-Deoxy-6,28-epoxy-25-methylmilbemycin B is also used as a subject of research and development in the fields of veterinary medicine and pest control. Further investigation into its properties and potential applications may lead to the discovery of new treatments and control methods for various parasitic and pest-related issues.
Check Digit Verification of cas no
The CAS Registry Mumber 51596-12-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,9 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 51596-12:
(7*5)+(6*1)+(5*5)+(4*9)+(3*6)+(2*1)+(1*2)=124
124 % 10 = 4
So 51596-12-4 is a valid CAS Registry Number.
51596-12-4Relevant articles and documents
Bioconversion of milbemycin-related compounds: Isolation and utilization of non-producer, strain RNBC-5-51
Nonaka, Koichi,Tsukiyama, Takahiro,Sato, Kazuo,Kumasaka, Chieko,Maruyama, Fumio,Yoshikawa, Hiroji
, p. 620 - 627 (1999)
A non-producing strain, the so-called strain RNBC-5-51 SANK 60198, was isolated during a screening program of strain improvement in the milbemycin production. Strain RNBC-5-51 indicated almost the same characteristics as those in the parent strain, that is, the abundant spore formation on agar media and the good growth in liquid media. But it does not produce any kind of milbemycins. In addition, strain RNBC-5-51 accumulated precursor-like compounds of milbemycin-polyketide, the production of which were inhibited by the addition of cerulenin. In the bioconversion experiments, strain RNBC-5-51 converted milbemycin β6 and A4 to milbemycin α14, and milbemycin β7 and A3 to milbemycin α11, respectively. This strain also converted milbemycin D and avermectin B(1a), to 26-(3-methyl-2-butenoyloxy)milbemycin D and 26-(3-methyl-2-butenoyloxy)avermectin B(1a), respectively. These results suggest that milbemycin α11 is biosynthesized through the same route as milbemycin α14, and the mutated step in strain RNBC-5-51 might be in the polyketide synthetic pathway of milbemycins. Strain RNBC-5-51 loses the ability for de novo synthesis of milbemycins, but it retains the ability to bioconvert the milbemycin skeleton. This strain might be useful for C-26 modification of milbemycin-related compounds.
