- HETEROCYCLIC COMPOUNDS AND USES THEREOF
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Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.
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- Compounds
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Compounds of formula I: [in-line-formulae]A-B-C??(I)[/in-line-formulae] and isomers, salts, solvates, chemically protected forms, and prodrugs thereof wherein: B is selected from the group consisting of: ?where RN is H or Me; or B is a divalent C5 heterocyclic residue containing one or two ring heteroatoms; A is: RA3 and RA5 are independently selected from halo, ORO and RAC, where RO is H or Me, and RAC is H or C1-4 alkyl; XA is selected from N and CRA4, where RA4 is selected from H, ORO, CH2OH, CO2H, NHSO2Me and NHCOMe; RA2 and RA6 are independently selected from H, halo and ORO; or RA3 and RA4 together with the carbon atoms to which they are attached, or RA2 and RA3 together with the carbon atoms to which they are attached, may form a C5-6 heterocylic or heteroaromatic ring, containing at least one nitrogen ring atom; where if X is not N, 1, 2, or 3 of RA2 to RA6 are not H; C is: ?where X is selected from N and CH, Y is selected from N and CH, and Z is selected from N and CRC6; RC3 is selected from H, halo and an optionally substituted N-containing C5-7 heterocyclic group; RC5 is a group selected from: ?which group may be selected by one or two C1-4 alkyl groups or a carboxy group; RC6 is H; or, when X and Y are N, RC5 and RC6 (when Z is CRC6) together with the carbon atoms to which they are attached may form a fused C6 aromatic ring selected from the group consisting of:
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Page/Page column 30
(2008/06/13)
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- Preparation and Structure-Activity Relationships of 4-Substituted Amino-2-methylpyridopyrimidines as Cytokinin Analogs
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Various 4-substituted amino derivatives of 2-methylpyridopyrimidine were prepared to investigate their structure-cytokinin activity relationships.Both an Amaranthus betacyanin and a lettuce seed germination bioassay revealed that most anilino and s
- Nishikawa, Shiro,Nishikimi, Yoshio,Maki, Shinji,Kumazawa, Zenzaburo,Kashimura, Naoki
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p. 1034 - 1038
(2007/10/02)
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- Syntheses of Some Azolopyridopyrimidines
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Syntheses of isomeric azolopyridopyrimidines are described.As starting material the corresponding pyridopyrimidines were used.It could be established that in many cases a transformation of a functional group with the purpose to form an annelated five-membered ring proceeded with ring opening at the pyrimidine part.Subsequent ring closure with one carbon synthons gave then the desired tricyclic heterocycles. - Keywords: Cyclization with C-N and N-N bond formation; Tricyclic heterocyclic compounds
- Petric, Andrej,Tisler, M.,Stanovnik, Branko
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p. 615 - 624
(2007/10/02)
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