51752-67-1

Basic information

• Product Name: Pyrido[3,4-d]pyrimidine, 4-chloro-
• Synonyms: Pyrido[3,4-d]pyrimidine, 4-chloro-;4-chloropyrido[3,4-d]pyrimidine;4-chloropyrido[3,4-d]pyrimidine hydrochloride
• CAS NO: 51752-67-1
• Molecular Formula: C₇H₄ClN₃
• Molecular Weight: 165.57976
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyrimidine series
• Mol File: 51752-67-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 108-110 °C
• Boiling Point: 316.1 °C at 760 mmHg
• Flash Point: 174.3 °C
• Appearance: white solid
• Density: 1.438 g/cm³
• Vapor Pressure: 0.000776mmHg at 25°C
• Refractive Index: 1.674
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.37±0.30(Predicted)
• CAS DataBase Reference: Pyrido[3,4-d]pyrimidine, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,4-d]pyrimidine, 4-chloro-(51752-67-1)
• EPA Substance Registry System: Pyrido[3,4-d]pyrimidine, 4-chloro-(51752-67-1)

Safety Data

• Hazardous Substances Data: 51752-67-1(Hazardous Substances Data)

Usage

Description

Pyrido[3,4-d]pyrimidine, 4-chlorois a chemical compound belonging to the pyrimidine family, characterized by the presence of a chlorine atom at the 4-position. It is known for its potential applications in various fields due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
Pyrido[3,4-d]pyrimidine, 4-chlorois used as a reactant for the synthesis of isomeric 4-substituted aminopyrido[4,3-d]pyrimidines. These synthesized compounds exhibit cytokinin activity, which plays a crucial role in cell signaling and growth regulation. The cytokinin activity of these compounds makes them valuable in the development of new drugs targeting various diseases and conditions related to cell growth and regulation.

InChI:InChI=1/C7H4ClN3/c8-7-5-1-2-9-3-6(5)10-4-11-7/h1-4H

Upstream product

• 7579-20-6 3-Aminopyridine-4-carboxylic acid 
• 64188-97-2 3-aminopyridine-4-carboxamide 
• 19178-25-7 4-Hydroxypyrido<3,4-d>pyrimidin 
• 19178-25-7 pyrido(3,4-d)pyrimidin-4(3H)-one 
• 19178-25-7 pyrido-<3,4-d>pyrimidin-4(3H)-one 

Downstream Products

• 186519-78-8 (3ethynyl-phenyl)-pyrido[3,4-d]pyrimidin-4-yl-amine hydrochloride 
• 1353967-45-9 4-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-pyrido[3,4-d]pyrimidine 
• 186519-50-6 (3-chloro-phenyl)-(pyrido[3,4-d]pyrimidin-4-yl)-amine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Preparation and Structure-Activity Relationships of 4-Substituted Amino-2-methylpyridopyrimidines as Cytokinin Analogs

Various 4-substituted amino derivatives of 2-methylpyridopyrimidine were prepared to investigate their structure-cytokinin activity relationships.Both an Amaranthus betacyanin and a lettuce seed germination bioassay revealed that most anilino and s

Syntheses of Some Azolopyridopyrimidines

Syntheses of isomeric azolopyridopyrimidines are described.As starting material the corresponding pyridopyrimidines were used.It could be established that in many cases a transformation of a functional group with the purpose to form an annelated five-membered ring proceeded with ring opening at the pyrimidine part.Subsequent ring closure with one carbon synthons gave then the desired tricyclic heterocycles. - Keywords: Cyclization with C-N and N-N bond formation; Tricyclic heterocyclic compounds