Nickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles
While esters are frequently used as traditional electrophiles in substitution chemistry, their application in cross-coupling chemistry is still in its infancy. This work demonstrates that methyl esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)?O bond under relatively mild reaction conditions at either 80 or 100 °C. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C=C bond, carbonyl-retentive products were formed by domino Heck/Suzuki–Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles are used.
Zheng, Yan-Long,Newman, Stephen G.
supporting information
p. 18159 - 18164
(2019/11/13)
PROCESS FOR THE PREPARATION OF 6-FLUORO-2-METHYL-1-INDANONE
A process for the preparation of 6-fluoro-2-methyl-l-indanone which relates to a process of preferential cyclization of (3-fluorophenyl)-isopropenyl-ketone to obtain 6-fluoro-2-methyl- 1-indanone regioisomer with respect to 4-fluoro-2-methyl-l-indanone regioisomer, is described.
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Page/Page column 5-7
(2008/06/13)
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