52045-42-8 Usage
General Description
4-fluoro-2-methyl-1-indanone is a chemical compound with the molecular formula C10H9FO. It is a derivative of indanone, which is a bicyclic aromatic ketone. 4-fluoro-2-methyl-1-indanone is used in organic synthesis and pharmaceutical research, and it is considered as a building block for the synthesis of various pharmaceuticals. It is also used as a precursor in the manufacturing of other chemicals. 4-fluoro-2-methyl-1-indanone has several potential applications in the pharmaceutical and chemical industries due to its versatile reactivity and functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 52045-42-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,4 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 52045-42:
(7*5)+(6*2)+(5*0)+(4*4)+(3*5)+(2*4)+(1*2)=88
88 % 10 = 8
So 52045-42-8 is a valid CAS Registry Number.
52045-42-8Relevant articles and documents
Nickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles
Zheng, Yan-Long,Newman, Stephen G.
supporting information, p. 18159 - 18164 (2019/11/13)
While esters are frequently used as traditional electrophiles in substitution chemistry, their application in cross-coupling chemistry is still in its infancy. This work demonstrates that methyl esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)?O bond under relatively mild reaction conditions at either 80 or 100 °C. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C=C bond, carbonyl-retentive products were formed by domino Heck/Suzuki–Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles are used.
