- The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi
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Heterologous expression of a unique biosynthetic gene cluster (BGC) comprising a highly reducing polyketide synthase and stand-alone thioesterase genes in Aspergillus oryzae enabled us to isolate a novel 34-membered polyene macrolide, phaeospelide A (1).
- Morishita, Yohei,Zhang, Huiping,Taniguchi, Tohru,Mori, Keiji,Asai, Teigo
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- Optically active isonitrile ligand for palladium-catalyzed enantioselective bis-silylation of carbon-carbon double bonds
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Intramolecular bis-silylation of homoallylic alcohols proceeded enantioselectively in the presence of a catalyst prepared from Pd(acac), and optically active isonitriles, derived from a common chiral source, (+)-ketopinic acid.
- Suginome, Michinori,Nakamura, Hiroshi,Ito, Yoshihiko
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p. 555 - 558
(2007/10/03)
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- Metabolites of Microorganisms. Sulfur-Containing Ansa Compounds of the Naphthomycin Type
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From a strain of Streptomyces (Tue 2357) in addition to naphthomycin A, 4 new yellow pigments were isolated and their structures determined by spectroscopic comparison with naphthomycin A.Whereas the naphthomycins D and E are simple derivatives of naphthomycin A, having OH and H, respectively, instead of Cl, the naphthomycins F and G contain an N-acetylcysteine residue linked to the aromatic moiety by a thioether group.Degradations with O3 yielded identical products from the naphthomycins A, D, F, and G, showing coincident configurations in parts of the molecules.Naphthomycin F shows some biological activity against gram-positive bacteria and fungi, although much weaker than naphthomycin A.The naphthomycins D, E, and G are inactive against microorganisms.
- Meyer, Michael,Keller-Schierlein, Walter,Megahed, Salva,Zaehner, Hans,Segre, Annalaura
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p. 1356 - 1364
(2007/10/02)
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- Facile access to (S)-1,2,4-butanetriol and its derivatives
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The synthesis of (S)-1,2,4-butanetriol from the readily available (S)-malic acid in one step using borane-dimethyl sulfide is described.
- Hanessian, Stephen,Ugolini, Antonio,Dube, Daniel,Glamyan, Ani
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p. 2146 - 2147
(2007/10/02)
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