- Metal-free access to 3-allyl-2-alkoxychromanonesviaphosphine-catalyzed alkoxy allylation of chromones with MBH carbonates and alcohols
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A metal-free access to 3-allyl-2-alkoxychromanones by PPh3-catalyzed alkoxy allylation of chromones with MBH carbonates and alcohols is described. This reaction is performed under mild conditions and it shows good functional group tolerance, providing a series of functionalized chromanones in moderate to high yields with excellent diastereoselectivities. Deuterium-labeling experiments to probe a possible mechanism and scale-up reaction were also conducted.
- Meng, Ling,Chang, Xiaoyong,Lin, Zhenyang,Wang, Jun (Joelle)
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supporting information
p. 2663 - 2667
(2021/04/07)
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- Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids useful for preventing asthmatic symptoms
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Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids having the structural formula: SPC1 Wherein R1 represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, or acyloxy; R2 represents hydrogen, lower alkyl, fluorinated lower alkyl, alkoxycarbonyl, carboxy, or lower alkyl carboxylic acid; Z represents cyano, carboxy, alkoxycarbonyl, or EQU1 wherein X represents amino, N-lower-alkylamino, hydroxylamino, N-lower-alkylhydroxylamino, ureido, piperidino, or anilino, with the proviso that when R2 represents hydrogen, Z represents cyano or EQU2 wherein X has the same meaning as given above; and wherein R2 and Z together may form a substituted pyrrole ring; and the corresponding non-toxic, pharmaceutically acceptable salts.
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