- Conversion of: N- acyl amidines to amidoximes: A convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
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An efficient method is described for the preparation of molnupiravir (EIDD-2801) an antiviral agent via regioselective conversion of an N-acyl-nucleoside intermediate, generated through stereo and regioselective glycosylation of protected ribose and N4-acetyl cytosine, to an amidoxime. This method avoids use of expensive starting materials, enzymes, complex reagents, and cumbersome purification procedures.
- Ahmed, Ajaz,Ahmed, Qazi Naveed,Mukherjee, Debaraj
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p. 36143 - 36147
(2021/12/04)
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- Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide
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In view of biological activities of azole nucleosides and apio-dideoxynucleoside, novel apio nucleoside analogues (1 and 2) with thiazole and triazole base moiety were synthesized using 2,3-O-isopropylidene-apio-β -D-furanose (3), which was prepared from D-mannose.
- Kim, Myong Jung,Jeong, Lak Shin,Kim, Joong Hyup,Shin, Ji Hye,Chung, Soon Yong,Lee, Sang Kook,Chun, Moon Woo
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p. 715 - 724
(2007/10/03)
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- A Simple Synthesis of α-D-Ribofuranosides
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The glycosylation of various aglycones with 5-O-benzoyl-2,3-O-isopropylidene-β-D-ribofuranosyl bromide (2) has been studied under different reaction conditions.It is possible to obtain high yields of α-linked ribofuranosides using methanol or methyl-2,3-O
- Bock, Klaus,Refn, Susanne
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p. 324 - 327
(2007/10/02)
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