5517-60-2Relevant articles and documents
Conversion of: N- acyl amidines to amidoximes: A convenient synthetic approach to molnupiravir (EIDD-2801) from ribose
Ahmed, Ajaz,Ahmed, Qazi Naveed,Mukherjee, Debaraj
, p. 36143 - 36147 (2021/12/04)
An efficient method is described for the preparation of molnupiravir (EIDD-2801) an antiviral agent via regioselective conversion of an N-acyl-nucleoside intermediate, generated through stereo and regioselective glycosylation of protected ribose and N4-acetyl cytosine, to an amidoxime. This method avoids use of expensive starting materials, enzymes, complex reagents, and cumbersome purification procedures.
A Simple Synthesis of α-D-Ribofuranosides
Bock, Klaus,Refn, Susanne
, p. 324 - 327 (2007/10/02)
The glycosylation of various aglycones with 5-O-benzoyl-2,3-O-isopropylidene-β-D-ribofuranosyl bromide (2) has been studied under different reaction conditions.It is possible to obtain high yields of α-linked ribofuranosides using methanol or methyl-2,3-O